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Study · Animal study (in vivo) · rat · 2003

3 results

Sustained release of human growth hormone from microcapsules prepared by a solvent evaporation technique.

Takada S, Yamagata Y, Misaki M, Taira K, Kurokawa T

Journal of controlled release : official journal of the Controlled Release Society1 Mar 2003Cited by 62 (Europe PMC)

PMID12628330 (opens in a new tab)DOI10.1016/s0168-3659(02)00494-7 (opens in a new tab)PepBankPUB-12628330
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In animal dosing experiments, smaller rhGH particles in microcapsules decreased initial in vivo release.

    In plain wordsIn animals, smaller growth hormone particles in microcapsules decreased initial release compared with larger particles.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseInitial release
    Study

    ratn: not reported in source

    Comparator
    larger rhGH particle size
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    As the particle size of rhGH decreased, the in vivo initial release decreased, while subsequent serum levels of rhGH in sustained release phase were higher.
    2 context sentences
    Summary · context
    Addition of zinc oxide to microcapsules resulted in higher serum levels than those prepared without zinc oxide, suggesting a stabilizing effect of zinc oxide after subcutaneous injection into rats.
    Summary · context
    Biodegradable microcapsules for sustained release of recombinant human growth hormone (rhGH) were prepared by a solid-in-oil-in-water (S/O/W) emulsion solvent evaporation technique using lyophilized protein microparticles.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In animal dosing experiments, smaller rhGH particles produced higher serum rhGH levels during sustained release.

    In plain wordsIn animals, smaller growth hormone particles produced higher sustained serum levels than larger particles.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSustained serum rhGH
    Study

    ratn: not reported in source

    Comparator
    larger rhGH particle size
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    As the particle size of rhGH decreased, the in vivo initial release decreased, while subsequent serum levels of rhGH in sustained release phase were higher.
    2 context sentences
    Summary · context
    Addition of zinc oxide to microcapsules resulted in higher serum levels than those prepared without zinc oxide, suggesting a stabilizing effect of zinc oxide after subcutaneous injection into rats.
    Summary · context
    Biodegradable microcapsules for sustained release of recombinant human growth hormone (rhGH) were prepared by a solid-in-oil-in-water (S/O/W) emulsion solvent evaporation technique using lyophilized protein microparticles.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, zinc oxide-containing rhGH microcapsules produced higher serum levels than microcapsules without zinc oxide after subcutaneous injection.

    In plain wordsIn rats, growth hormone microcapsules with zinc oxide produced higher serum levels than microcapsules without zinc oxide.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSerum rhGH with zinc oxide
    Study

    ratn: not reported in source

    Comparator
    microcapsules without zinc oxide
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Addition of zinc oxide to microcapsules resulted in higher serum levels than those prepared without zinc oxide, suggesting a stabilizing effect of zinc oxide after subcutaneous injection into rats.
    1 context sentence
    Summary · context
    Biodegradable microcapsules for sustained release of recombinant human growth hormone (rhGH) were prepared by a solid-in-oil-in-water (S/O/W) emulsion solvent evaporation technique using lyophilized protein microparticles.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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