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Study · Animal study (in vivo) · rat · 2003

2 results

Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function.

Kuo JJ, Silva AA, Hall JE

Hypertension (Dallas, Tex. : 1979)30 Dec 2002Cited by 84 (Europe PMC)

PMID12623994 (opens in a new tab)DOI10.1161/01.hyp.0000048194.97428.1a (opens in a new tab)PepBankPUB-12623994
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, chronic intracerebroventricular infusion of the MC3/4-R agonist MTII transiently decreased food intake from 23 to 10 g/d.

    In plain wordsIn rats, MTII infused into the brain briefly reduced daily food intake.

    Peptide
    Melanotan II
    Outcome
    DecreaseFood intake
    Study

    ratn = 7

    Comparator
    Saline
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    10 ng/h · intracerebroventricular · 14 daysAs given in this study (rat).

    Measurements

    Food intake before MTII
    23 g/d
    control period
    Food intake during MTII
    10 g/d
    MTII infusion

    Source sentences

    Summary
    MC4-R activation transiently decreased food intake from 23+/-1 to 10+/-2 g/d.
    1 context sentence
    Summary · context
    In experiment 1, after a 5-day control period, rats were administered the MC3/4-R agonist MTII (n=7, 10 ng/h ICV) or 0.9% saline (n=6, ICV) for 14 days, followed by a 5-day recovery period.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, chronic MC3/4-R activation by MTII increased mean arterial pressure by 7 mm Hg despite reduced food intake.

    In plain wordsIn rats, MTII infused into the brain raised blood pressure even though the animals ate less.

    Peptide
    Melanotan II
    Outcome
    IncreaseMean arterial pressure
    Study

    ratn = 7

    Comparator
    Saline
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    10 ng/h · intracerebroventricular · 14 daysAs given in this study (rat).

    Measurements

    Mean arterial pressure change
    7 mm Hg
    MTII infusion

    Source sentences

    Summary
    Despite the hypophagia, MC3/4-R activation increased MAP by 7+/-1 mm Hg.
    1 context sentence
    Summary · context
    In experiment 1, after a 5-day control period, rats were administered the MC3/4-R agonist MTII (n=7, 10 ng/h ICV) or 0.9% saline (n=6, ICV) for 14 days, followed by a 5-day recovery period.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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