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Study · Measured the body's own peptide · 2003

1 result

The soya isoflavone content of rat diet can increase anxiety and stress hormone release in the male rat.

Hartley DE, Edwards JE, Spiller CE, Alom N, Tucci S, Seth P, Forsling ML, File SE

Psychopharmacology5 Mar 2003Cited by 53 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In male rats, diets with and without soya isoflavones gave no difference in the body's own oxytocin concentrations after handling stress.

    In plain wordsIn male rats, a diet with soya isoflavones did not change the body's own oxytocin levels compared with an isoflavone-free diet.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin concentration with iso-150 versus iso-free diet
    Study

    ratn: not reported in source

    Comparator
    Isoflavone-free diet
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The groups did not differ in food or water intake, body weight or oxytocin concentrations.
    2 context sentences
    Summary · context
    To determine whether behaviour in two animal tests of anxiety, and stress hormone production, would differ between rats that were fed a diet which was free of soya isoflavones and other phytoestrogens (iso-free) and those that were fed a diet which contained 150 microg/g of the isoflavones genistein…
    Summary · context
    Vasopressin and oxytocin concentrations were determined after brief handling stress.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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