Vasorelaxations induced by calcitonin gene-related peptide, vasoactive intestinal peptide, and acetylcholine in aortic rings of endothelial and inducible nitric oxide synthase-knockout mice.

Chan SL, Fiscus RR

Journal of cardiovascular pharmacology1 Mar 2003Cited by 7 (Europe PMC)

PMID12605022DOI10.1097/00005344-200303000-00012PepBankPUB-12605022

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In aortic rings from control and iNOS-knockout mice, VIP relaxation was completely dependent on the endothelium.
In plain wordsIn lab tests on mouse aortic rings, VIP relaxed the vessel only when the inner lining was present.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableEndothelium dependence of VIP relaxation
Study
mousen: not reported in source
aortic rings
Comparator
Wild-type control mice
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
The vasorelaxant responses to VIP were completely dependent on endothelium in control and iNOS (-/-) mice.
1 context sentence(design, population, supporting numbers)
Summary · context
to determine if vasorelaxant responses to calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), and acetylcholine are altered in aortic rings of mice lacking genetic expression of endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS) genes (i.e., e…
Report a problemFND-1260502201
02LabEx vivo tissueActivity measurement
Maximum relaxation to VIP was significantly greater in aortic rings of iNOS-knockout mice than in control mice.
In plain wordsIn lab tests, VIP relaxed aortic rings from iNOS-knockout mice more than rings from normal mice.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseMaximum VIP relaxation in iNOS-knockout aortas
Study
mousen: not reported in source
aortic rings
Comparator
Wild-type control mice
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Measurements
Maximum relaxation
77.4%
iNOS-/- mice
Maximum relaxation
64%
control mice
Source sentences
Summary
Maximum relaxations to VIP in iNOS (-/-) mice (77.4 +/- 2.7%) were significantly greater than in control mice (64.0 +/- 5.5%).
1 context sentence(design, population, supporting numbers)
Summary · context
to determine if vasorelaxant responses to calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), and acetylcholine are altered in aortic rings of mice lacking genetic expression of endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS) genes (i.e., e…
Report a problemFND-1260502202
03LabEx vivo tissueActivity measurement
VIP relaxation of endothelium-intact aortic rings from eNOS-knockout mice was greatly attenuated compared with control mice.
In plain wordsIn lab tests, VIP relaxed aortic rings from eNOS-knockout mice much less than rings from normal mice.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP relaxation in eNOS-knockout aortas
Study
mousen: not reported in source
aortic rings
Comparator
Wild-type control mice
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Measurements
Relaxation to VIP
18.3%
eNOS-/- mice
Relaxation to VIP
64%
control mice
Source sentences
Summary
Vasorelaxant responses to VIP in eNOS (-/-) aortic rings were also endothelium-dependent, but responses were greatly attenuated compared with wild-type mice. Relaxations induced by VIP (1 x 10 ) in endothelium-intact aortic rings of eNOS (-/-) mice and control mice were 18.3 +/- 5.4% and 64.0 +/- 5.5%, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
to determine if vasorelaxant responses to calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), and acetylcholine are altered in aortic rings of mice lacking genetic expression of endothelial nitric oxide synthase (eNOS) or inducible nitric oxide synthase (iNOS) genes (i.e., e…
Report a problemFND-1260502203

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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