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Study · Animal study (in vivo) · rat · 2002

3 results

[The role of non-NMDA glutamate receptors in the EEG effects of chronic administration of noopept GVS-111 in awake rats].

Kovalev GI, Vorob'ev VV

Eksperimental'naia i klinicheskaia farmakologiia1 Nov 2002

PMID12596524 (opens in a new tab)PepBankPUB-12596524
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In awake rats, noopept's alpha EEG response inverted after the sixth injection and almost vanished after the ninth injection.

    In plain wordsIn rats, noopept's alpha EEG response reversed after repeated injections and then almost disappeared.

    Peptide
    Noopept (omberacetam)
    Outcome
    MixedAlpha EEG response during repeated administration
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.2 mg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The acute reactions (characteristic of nootropes) in the alpha and beta ranges of EEG exhibited inversion after the 6th injection of noopept and almost completely vanished after the 9th injection.
    1 context sentence
    Summary · context
    Participation of the non-NMDA glutamate receptor subtype in the formation of the EEG frequency spectrum was studied in wakeful rats upon a long-term (10 x 0.2 mg/kg, s.c.) administration of the nootropic dipeptide GVS-111 (noopept or N-phenylacetyl-L-prolyglycine ethylate).
  2. 02AnimalAnimal study (in vivo)Mechanism

    In awake rats, noopept's beta EEG response inverted after the sixth injection and almost vanished after the ninth injection.

    In plain wordsIn rats, noopept's beta EEG response reversed after repeated injections and then almost disappeared.

    Peptide
    Noopept (omberacetam)
    Outcome
    MixedBeta EEG response during repeated administration
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.2 mg/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The acute reactions (characteristic of nootropes) in the alpha and beta ranges of EEG exhibited inversion after the 6th injection of noopept and almost completely vanished after the 9th injection.
    1 context sentence
    Summary · context
    Participation of the non-NMDA glutamate receptor subtype in the formation of the EEG frequency spectrum was studied in wakeful rats upon a long-term (10 x 0.2 mg/kg, s.c.) administration of the nootropic dipeptide GVS-111 (noopept or N-phenylacetyl-L-prolyglycine ethylate).

Studies that did not test the peptide alone1

In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Noopept (omberacetam).

  1. 03AnimalNot a test of Noopept (omberacetam) aloneAnimal study (in vivo)Mechanism

    In awake rats receiving GVS-111, preliminary GDEE administration restored the EEG pattern observed at the sixth GVS-111 dose.

    In plain wordsIn rats receiving GVS-111, GDEE restored the EEG pattern seen at the sixth GVS-111 dose.

    Peptide
    Noopept (omberacetam)
    Outcome
    MixedEEG response to GDEE
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Preliminary introduction of the non-NMDA antagonist GDEE (glutamic acid diethyl ester) in a dose of 1 mumole into the lateral ventricle restored the EEG pattern observed upon the 6th dose of GVS-111.
    1 context sentence
    Summary · context
    Participation of the non-NMDA glutamate receptor subtype in the formation of the EEG frequency spectrum was studied in wakeful rats upon a long-term (10 x 0.2 mg/kg, s.c.) administration of the nootropic dipeptide GVS-111 (noopept or N-phenylacetyl-L-prolyglycine ethylate).

    In this study, Noopept (omberacetam) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Noopept (omberacetam).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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