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Study · Animal study (in vivo) · rat · 2003

4 results

The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat.

Ter Laak MP, Brakkee JH, Adan RA, Hamers FP, Gispen WH

European journal of pharmacology1 Feb 2003Cited by 12 (Europe PMC)

PMID12591111 (opens in a new tab)DOI10.1016/s0014-2999(02)02945-x (opens in a new tab)PepBankPUB-12591111
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a sciatic nerve crush, melanotan II 20 microg/kg every 48 h significantly enhanced recovery of sensory function.

    In plain wordsIn rats with a crushed sciatic nerve, melanotan II at the middle dose improved recovery of sensation.

    Peptide
    Melanotan II
    Outcome
    IncreaseRecovery of sensory function after sciatic nerve crush
    Study

    ratn: not reported in source

    Rat sciatic nerve crush
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    20 microg/kg per 48 h · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Melanotan-II significantly enhanced the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 microg kg(-1) per 48 h, s.c., but not at a dose of 2 or 50 microg kg(-1).
    1 context sentence
    Summary · context
    The sciatic nerve crush model was used as a paradigm to investigate the neurotrophic properties of melanotan-II.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a sciatic nerve crush, melanotan II 2 microg/kg did not enhance recovery of sensory function.

    In plain wordsIn rats with a crushed sciatic nerve, the lowest dose of melanotan II did not improve recovery of sensation.

    Peptide
    Melanotan II
    Outcome
    No significant changeRecovery of sensory function after sciatic nerve crush
    Study

    ratn: not reported in source

    Rat sciatic nerve crush
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    2 microg/kg per 48 h · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Melanotan-II significantly enhanced the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 microg kg(-1) per 48 h, s.c., but not at a dose of 2 or 50 microg kg(-1).
    1 context sentence
    Summary · context
    The sciatic nerve crush model was used as a paradigm to investigate the neurotrophic properties of melanotan-II.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with a sciatic nerve crush, melanotan II 50 microg/kg did not enhance recovery of sensory function.

    In plain wordsIn rats with a crushed sciatic nerve, the highest dose of melanotan II did not improve recovery of sensation.

    Peptide
    Melanotan II
    Outcome
    No significant changeRecovery of sensory function after sciatic nerve crush
    Study

    ratn: not reported in source

    Rat sciatic nerve crush
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50 microg/kg per 48 h · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Melanotan-II significantly enhanced the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 microg kg(-1) per 48 h, s.c., but not at a dose of 2 or 50 microg kg(-1).
    1 context sentence
    Summary · context
    The sciatic nerve crush model was used as a paradigm to investigate the neurotrophic properties of melanotan-II.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, melanotan II partially protected the nerve from a toxic neuropathy induced by cisplatin.

    In plain wordsIn rats, melanotan II partly protected nerves from damage caused by the drug cisplatin.

    Peptide
    Melanotan II
    Outcome
    IncreaseProtection from cisplatin-induced toxic neuropathy
    Study

    ratn: not reported in source

    Rat cisplatin-induced toxic neuropathy
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, we observed that melanotan-II also possesses neuroprotective properties, as it partially protected the nerve from a toxic neuropathy induced by cisplatin.
    1 context sentence
    Summary · context
    The sciatic nerve crush model was used as a paradigm to investigate the neurotrophic properties of melanotan-II.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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