[Effect of dipeptide vilon on emotional stress resistance in rats].

Koplik EV, Meshcheriakov AF, Pertsov SS, Umriukhin PE, Sudakov KV, Khavinson VKh

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Nov 2002

PMID12587272PepBankPUB-12587272

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In male Wistar rats, vilon increased emotional stress resistance according to open field prognostic indices.
In plain wordsIn rats, vilon increased emotional stress resistance based on open field behaviour.
Peptide
Vilon (KE)
Outcome
IncreaseEmotional stress resistance
Study
ratn: not reported in source
Male Wistar rats
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
It is shown that intraperitoneal vilon injection rises the resistance against emotional stress according to prognostic indexes open field behaviour.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic thymomimetic vilon on open field behaviour, immediate early gene c-Fos expression in paraventricular hypothalamus properties of organs sensitive to emotional stress, and characteristics of albumin in the blood plasma in male Wistar rats, were investigated and are discussed in the article.
Report a problemFND-1258727201
02AnimalAnimal study (in vivo)Efficacy outcome
In male Wistar rats, vilon inhibited adrenal hypertrophy.
In plain wordsIn rats, vilon inhibited enlargement of the adrenal glands.
Peptide
Vilon (KE)
Outcome
DecreaseAdrenal hypertrophy
Study
ratn: not reported in source
Male Wistar rats
Outcome group
Organ injury · Endocrine and hormones
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Vilon administration also inhibits hypertrophy of the adrenals, involution of the thymus, and elevates concentration of albumin in the blood plasma.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic thymomimetic vilon on open field behaviour, immediate early gene c-Fos expression in paraventricular hypothalamus properties of organs sensitive to emotional stress, and characteristics of albumin in the blood plasma in male Wistar rats, were investigated and are discussed in the article.
Report a problemFND-1258727202
03AnimalAnimal study (in vivo)Efficacy outcome
In male Wistar rats, vilon inhibited thymus involution.
In plain wordsIn rats, vilon inhibited shrinkage of the thymus.
Peptide
Vilon (KE)
Outcome
DecreaseThymus involution
Study
ratn: not reported in source
Male Wistar rats
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Vilon administration also inhibits hypertrophy of the adrenals, involution of the thymus, and elevates concentration of albumin in the blood plasma.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic thymomimetic vilon on open field behaviour, immediate early gene c-Fos expression in paraventricular hypothalamus properties of organs sensitive to emotional stress, and characteristics of albumin in the blood plasma in male Wistar rats, were investigated and are discussed in the article.
Report a problemFND-1258727203
04AnimalAnimal study (in vivo)Efficacy outcome
In male Wistar rats, vilon increased plasma albumin concentration.
In plain wordsIn rats, vilon increased blood plasma albumin levels.
Peptide
Vilon (KE)
Outcome
IncreasePlasma albumin concentration
Study
ratn: not reported in source
Male Wistar rats
Outcome group
Blood biochemical markers · Whole body
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Vilon administration also inhibits hypertrophy of the adrenals, involution of the thymus, and elevates concentration of albumin in the blood plasma.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic thymomimetic vilon on open field behaviour, immediate early gene c-Fos expression in paraventricular hypothalamus properties of organs sensitive to emotional stress, and characteristics of albumin in the blood plasma in male Wistar rats, were investigated and are discussed in the article.
Report a problemFND-1258727204
05AnimalAnimal study (in vivo)Mechanism
In male Wistar rats, vilon reduced hypothalamic Fos-immunoreactive neuron counts, especially in rats resistant to emotional stress.
In plain wordsIn rats, vilon reduced hypothalamic neurons with detectable Fos, especially in animals resistant to emotional stress.
Peptide
Vilon (KE)
Outcome
DecreaseFos-immunoreactive neurons in paraventricular hypothalamus
Study
ratn: not reported in source
Male Wistar rats
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
The number of Fos-immunoreactive neurons in the paraventricular hypothalamus was lower after vilon administration especially in rats resistant against emotional stress.
1 context sentence(design, population, supporting numbers)
Summary · context
Effects of synthetic thymomimetic vilon on open field behaviour, immediate early gene c-Fos expression in paraventricular hypothalamus properties of organs sensitive to emotional stress, and characteristics of albumin in the blood plasma in male Wistar rats, were investigated and are discussed in the article.
Report a problemFND-1258727205

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 17:05 UTC
Study results updated
Version 1
21 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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