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Study · Animal study (in vivo) · rat · 2003

5 results

PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex: identification by ddPCR.

Costain WJ, Mishra RK

Peptides1 Jan 2003Cited by 6 (Europe PMC)

PMID12576095 (opens in a new tab)DOI10.1016/s0196-9781(02)00286-3 (opens in a new tab)PepBankPUB-12576095
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male Sprague-Dawley rats, PLG treatment yielded three down-regulated bands in a screen of 2400 genes.

    In plain wordsIn rats, PLG treatment reduced expression in three bands detected during gene screening.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseDown-regulated gene bands
    Study

    ratn: not reported in source

    male Sprague-Dawley rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    20 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    A total of 2400 genes were screened and 3 down-regulated bands were identified in the PLG-treated samples.
    1 context sentence
    Summary · context
    Differential display polymerase chain reaction (ddPCR) was utilized to identify genes that are regulated by protracted PLG treatment (20 mg/kg, i.p. for 28 days) in male Sprague-Dawley rats.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rat tissue, PLG treatment decreased the 2.3 kb PRG1 mRNA species by 65%.

    In plain wordsIn rats, PLG treatment reduced an RNA species identified as hnRNP-L.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreasehnRNP-L mRNA
    Study

    ratn: not reported in source

    male Sprague-Dawley rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    20 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Measurements

    PRG1 mRNA decrease
    65%
    PLG-treated tissue

    Source sentences

    Summary
    Northern hybridization experiments with PRG1 revealed a 2.3 kb mRNA species that was decreased by 65% in the PLG-treated tissue.
    2 context sentences
    Summary · context
    Open reading frame analysis provided a putative amino acid sequence consistent with the identity of PRG1 as rat hnRNP-L.
    Summary · context
    Differential display polymerase chain reaction (ddPCR) was utilized to identify genes that are regulated by protracted PLG treatment (20 mg/kg, i.p. for 28 days) in male Sprague-Dawley rats.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, PLG treatment significantly decreased striatal hnRNP-L protein by 71%.

    In plain wordsIn rats, PLG treatment reduced hnRNP-L protein in the striatum.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseStriatal hnRNP-L protein
    Study

    ratn: not reported in source

    male Sprague-Dawley rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    20 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Measurements

    hnRNP-L decrease
    71%
    striatum of PLG-treated animals

    Source sentences

    Summary
    Western blot analysis revealed significantly decreased hnRNP-L levels in the striatum and pre-frontal cortex (but not the nucleus accumbens) by 71 and 61%, respectively of PLG-treated animals.
    1 context sentence
    Summary · context
    Differential display polymerase chain reaction (ddPCR) was utilized to identify genes that are regulated by protracted PLG treatment (20 mg/kg, i.p. for 28 days) in male Sprague-Dawley rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, PLG treatment significantly decreased pre-frontal cortex hnRNP-L protein by 61%.

    In plain wordsIn rats, PLG treatment reduced hnRNP-L protein in the pre-frontal cortex.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreasePre-frontal cortex hnRNP-L protein
    Study

    ratn: not reported in source

    male Sprague-Dawley rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    20 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Measurements

    hnRNP-L decrease
    61%
    pre-frontal cortex of PLG-treated animals

    Source sentences

    Summary
    Western blot analysis revealed significantly decreased hnRNP-L levels in the striatum and pre-frontal cortex (but not the nucleus accumbens) by 71 and 61%, respectively of PLG-treated animals.
    1 context sentence
    Summary · context
    Differential display polymerase chain reaction (ddPCR) was utilized to identify genes that are regulated by protracted PLG treatment (20 mg/kg, i.p. for 28 days) in male Sprague-Dawley rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, PLG treatment did not significantly decrease hnRNP-L protein in the nucleus accumbens.

    In plain wordsIn rats, PLG treatment did not significantly decrease hnRNP-L protein in the nucleus accumbens.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeNucleus accumbens hnRNP-L protein
    Study

    ratn: not reported in source

    male Sprague-Dawley rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    20 mg/kg · intraperitoneal · 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Western blot analysis revealed significantly decreased hnRNP-L levels in the striatum and pre-frontal cortex (but not the nucleus accumbens) by 71 and 61%, respectively of PLG-treated animals.
    1 context sentence
    Summary · context
    Differential display polymerase chain reaction (ddPCR) was utilized to identify genes that are regulated by protracted PLG treatment (20 mg/kg, i.p. for 28 days) in male Sprague-Dawley rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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