The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease.

Tatebayashi Y, Lee MH, Li L, Iqbal K, Grundke-Iqbal I

Acta neuropathologica19 Nov 2002Cited by 82 (Europe PMC)

PMID12557008DOI10.1007/s00401-002-0636-3PepBankPUB-12557008

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In adult female rats, intraperitoneal Cerebrolysin enhanced dentate gyrus neurogenesis.
In plain wordsIn rats, Cerebrolysin increased new neuron formation in the dentate gyrus.
Peptide
Cerebrolysin
Outcome
IncreaseDentate gyrus neurogenesis
Study
ratn: not reported in source
normal adult female rats
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Intraperitoneal administration of Cerebrolysin enhanced dentate gyrus neurogenesis and maze performance of 8- to 12-month-old female rats.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we investigated the effect of changes in the neurotrophic environment on neurogenesis in cultured rat hippocampal progenitors and in normal adult rats as models.
Report a problemFND-1255700804
02AnimalAnimal study (in vivo)Efficacy outcome
In adult female rats, intraperitoneal Cerebrolysin enhanced maze performance.
In plain wordsIn rats, Cerebrolysin improved maze performance.
Peptide
Cerebrolysin
Outcome
IncreaseMaze performance
Study
ratn: not reported in source
normal adult female rats
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
Intraperitoneal administration of Cerebrolysin enhanced dentate gyrus neurogenesis and maze performance of 8- to 12-month-old female rats.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we investigated the effect of changes in the neurotrophic environment on neurogenesis in cultured rat hippocampal progenitors and in normal adult rats as models.
Report a problemFND-1255700805
03LabIn vitro (cells)Efficacy outcome
In cultured adult rat hippocampal progenitors, Cerebrolysin increased neuron-like differentiated cells.
In plain wordsIn cells from adult rats, Cerebrolysin increased neuron-like differentiation.
Peptide
Cerebrolysin
Outcome
IncreaseNeuron-like differentiation
Study
ratn: not reported in source
adult rat hippocampal progenitors
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Cerebrolysin, a neurotrophic drug which has been shown to improve cognition and mood of AD patients, was found to increase neuron-like differentiated adult rat hippocampal progenitors in culture both by reducing apoptosis and by counteracting the FGF-2-induced polarity shift.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we investigated the effect of changes in the neurotrophic environment on neurogenesis in cultured rat hippocampal progenitors and in normal adult rats as models.
Report a problemFND-1255700801
04LabIn vitro (cells)Efficacy outcome
In cultured adult rat hippocampal progenitors, Cerebrolysin reduced apoptosis.
In plain wordsIn cells from adult rats, Cerebrolysin reduced cell death.
Peptide
Cerebrolysin
Outcome
DecreaseApoptosis
Study
ratn: not reported in source
adult rat hippocampal progenitors
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Cerebrolysin, a neurotrophic drug which has been shown to improve cognition and mood of AD patients, was found to increase neuron-like differentiated adult rat hippocampal progenitors in culture both by reducing apoptosis and by counteracting the FGF-2-induced polarity shift.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we investigated the effect of changes in the neurotrophic environment on neurogenesis in cultured rat hippocampal progenitors and in normal adult rats as models.
Report a problemFND-1255700802
05LabIn vitro (cells)Mechanism
In cultured adult rat hippocampal progenitors, Cerebrolysin counteracted the FGF-2-induced polarity shift.
In plain wordsIn cells from adult rats, Cerebrolysin counteracted the polarity shift induced by FGF-2.
Peptide
Cerebrolysin
Outcome
DecreaseFGF-2-induced polarity shift
Study
ratn: not reported in source
adult rat hippocampal progenitors
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Cerebrolysin, a neurotrophic drug which has been shown to improve cognition and mood of AD patients, was found to increase neuron-like differentiated adult rat hippocampal progenitors in culture both by reducing apoptosis and by counteracting the FGF-2-induced polarity shift.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we investigated the effect of changes in the neurotrophic environment on neurogenesis in cultured rat hippocampal progenitors and in normal adult rats as models.
Report a problemFND-1255700803

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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