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Study · Animal study (in vivo) · chicken · 2003

3 results

In vivo thymulin treatments enhance avian lung natural killer cell cytotoxicity in response to infectious bronchitis virus.

Oliver MA, Marsh JA

International immunopharmacology1 Jan 2003Cited by 6 (Europe PMC)

PMID12538040 (opens in a new tab)DOI10.1016/s1567-5769(02)00236-9 (opens in a new tab)PepBankPUB-12538040
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In IBV-infected chickens, thymulin enhanced NK cytotoxicity, with greatest enhancement after post-infection treatment at 10 days post-infection.

    In plain wordsIn infected chickens, thymulin enhanced NK cytotoxicity compared with diluent controls, most strongly at 10 days after infection.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseNK cytotoxicity
    Study

    chickenn: not reported in source

    IBV-infected K-strain chickens
    Comparator
    ZnCl(2)-containing CMC diluent
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (chicken).

    Source sentences

    Summary
    The results of these experiments showed that in vivo thymulin treatments enhance NK cytotoxicity. The greatest enhancement of NK cytotoxicity was observed at 10 days post-infection in those chickens that began receiving thymulin after infection.
    2 context sentences
    Summary · context
    Five and a half-week-old K-strain chickens infected with avian infectious bronchitis virus (IBV) served as the model for these experiments.
    Summary · context
    The controls received daily injections of the ZnCl(2)-containing carboxymethyl-cellulose (CMC) diluent.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In infected chickens, thymulin at 50 ng/100 g depressed NK cytolytic activity compared with 10 ng/100 g.

    In plain wordsIn infected chickens, thymulin at 50 ng/100 g reduced NK cytolytic activity compared with 10 ng/100 g.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseNK cytolytic activity at high dose versus low dose
    Study

    chickenn: not reported in source

    IBV-infected K-strain chickens
    Comparator
    10 ng/100 g body weight thymulin
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    50 ng/100 g body weight · injectionAs given in this study (chicken).

    Source sentences

    Summary
    Dose-response experiments found that the 50 ng/100 g body weight (Bwt) dose significantly depressed the cytolytic activity of the NK cells in comparison to either the 10 ng/100 g Bwt dose or the control.
    2 context sentences
    Summary · context
    Five and a half-week-old K-strain chickens infected with avian infectious bronchitis virus (IBV) served as the model for these experiments.
    Summary · context
    The controls received daily injections of the ZnCl(2)-containing carboxymethyl-cellulose (CMC) diluent.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In infected chickens, thymulin at 50 ng/100 g depressed NK cytolytic activity compared with control.

    In plain wordsIn infected chickens, thymulin at 50 ng/100 g reduced NK cytolytic activity compared with control.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseNK cytolytic activity at high dose versus control
    Study

    chickenn: not reported in source

    IBV-infected K-strain chickens
    Comparator
    ZnCl(2)-containing CMC diluent
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    50 ng/100 g body weight · injectionAs given in this study (chicken).

    Source sentences

    Summary
    Dose-response experiments found that the 50 ng/100 g body weight (Bwt) dose significantly depressed the cytolytic activity of the NK cells in comparison to either the 10 ng/100 g Bwt dose or the control.
    2 context sentences
    Summary · context
    Five and a half-week-old K-strain chickens infected with avian infectious bronchitis virus (IBV) served as the model for these experiments.
    Summary · context
    The controls received daily injections of the ZnCl(2)-containing carboxymethyl-cellulose (CMC) diluent.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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