Skip to content

Study · Animal study (in vivo) · rat · 2002

2 results

Cycloheximide prevents inhibition of expression of immediate early gene c-fos in paraventricular nuclei of rat hypothalamus produced by delta sleep-inducing peptide.

Umriukhin PE

Bulletin of experimental biology and medicine1 Sept 2002Cited by 1 (Europe PMC)

PMID12511984 (opens in a new tab)DOI10.1023/a:1021430828877 (opens in a new tab)PepBankPUB-12511984
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats given intracerebroventricular saline, DSIP inhibited expression of the c-fos gene in hypothalamic paraventricular nuclei.

    In plain wordsIn rats, DSIP lowered activity of the c-fos gene in a stress-related brain area.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Decreasec-fos expression in hypothalamic paraventricular nuclei
    Study

    ratn: not reported in source

    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Delta-sleep-inducing peptide inhibited expression of the c-fos gene in rats receiving intracerebroventricular injection of physiological saline.
    1 context sentence
    Summary · context
    We studied expression of the immediate early gene c-fos in hypothalamic paraventricular nuclei in rats with different prognostic resistance to emotional stress receiving delta-sleep-inducing peptide after intracerebroventricular administration of cycloheximide.

Studies that did not test the peptide alone1

In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Delta sleep-inducing peptide (DSIP).

  1. 02AnimalNot a test of Delta sleep-inducing peptide (DSIP) aloneAnimal study (in vivo)Mechanism

    In rats, pretreatment with the protein synthesis blocker cycloheximide abolished the changes in c-fos expression that DSIP produced.

    In plain wordsIn rats, a protein synthesis blocker removed the change in c-fos gene activity that DSIP caused.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicablec-fos expression after cycloheximide pretreatment
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Pretreatment with the protein synthesis blocker cycloheximide abolished changes produced by delta-sleep-inducing peptide.
    1 context sentence
    Summary · context
    We studied expression of the immediate early gene c-fos in hypothalamic paraventricular nuclei in rats with different prognostic resistance to emotional stress receiving delta-sleep-inducing peptide after intracerebroventricular administration of cycloheximide.

    In this study, Delta sleep-inducing peptide (DSIP) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Delta sleep-inducing peptide (DSIP).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.