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Study · In vitro (cells) · 2002

6 results

[Effect of thymic peptides on the functional activity of phagocytic cells of donor peripheral blood].

Dambaeva SV, Kim KF, Mazurov DV, Deĭgin VI

Zhurnal mikrobiologii, epidemiologii i immunobiologii1 Nov 2002Cited by 1 (Europe PMC)

PMID12506630 (opens in a new tab)PepBankPUB-12506630
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In donor blood cells, Thymogen stimulated neutrophil ingestive activity.

    In plain wordsIn cells from donor blood, Thymogen increased neutrophil ingestion activity.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseNeutrophil ingestive activity
    Study

    Humann: not reported in source

    Donor peripheral blood phagocytic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 mMAs given in this study (Human).

    Source sentences

    Summary
    The preparations Thymogen, Neogen and Thymodepressin in a dose of 10 mM produced a stimulating effect on the ingestive activity of the neutrophil, but not monocytic, population.
    2 context sentences
    Summary · context
    The direct action of synthetic peptide preparations, analogous to thymic hormones, on the functions of phagocytic cells was studied.
    Title · context
    [Effect of thymic peptides on the functional activity of phagocytic cells of donor peripheral blood].
  2. 02LabIn vitro (cells)Activity measurement

    In donor blood cells, Thymogen did not stimulate monocyte ingestive activity.

    In plain wordsIn cells from donor blood, Thymogen did not increase monocyte ingestion activity.

    Peptide
    Thymogen (oglufanide)
    Outcome
    No significant changeMonocyte ingestive activity
    Study

    Humann: not reported in source

    Donor peripheral blood phagocytic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 mMAs given in this study (Human).

    Source sentences

    Summary
    The preparations Thymogen, Neogen and Thymodepressin in a dose of 10 mM produced a stimulating effect on the ingestive activity of the neutrophil, but not monocytic, population.
    2 context sentences
    Summary · context
    The direct action of synthetic peptide preparations, analogous to thymic hormones, on the functions of phagocytic cells was studied.
    Title · context
    [Effect of thymic peptides on the functional activity of phagocytic cells of donor peripheral blood].
  3. 03LabIn vitro (cells)Activity measurement

    In donor blood phagocytes, Thymogen increased spontaneous chemiluminescence.

    In plain wordsIn cells from donor blood, Thymogen increased spontaneous light emission associated with active oxygen production.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseSpontaneous chemiluminescence
    Study

    Humann: not reported in source

    Donor peripheral blood phagocytic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 mMAs given in this study (Human).

    Source sentences

    Summary
    The characteristics of spontaneous chemiluminescence (CL) reflecting the basal level of the synthesis of the active forms of oxygen and CL induced by opsomized zymosan significantly increased also in those cases when the preparations were used in a dose of 10 mM.
    2 context sentences
    Summary · context
    The direct action of synthetic peptide preparations, analogous to thymic hormones, on the functions of phagocytic cells was studied.
    Title · context
    [Effect of thymic peptides on the functional activity of phagocytic cells of donor peripheral blood].
  4. 04LabIn vitro (cells)Activity measurement

    In donor blood phagocytes, Thymogen increased zymosan-induced chemiluminescence.

    In plain wordsIn cells from donor blood, Thymogen increased zymosan-induced light emission associated with active oxygen production.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseZymosan-induced chemiluminescence
    Study

    Humann: not reported in source

    Donor peripheral blood phagocytic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 mMAs given in this study (Human).

    Source sentences

    Summary
    The characteristics of spontaneous chemiluminescence (CL) reflecting the basal level of the synthesis of the active forms of oxygen and CL induced by opsomized zymosan significantly increased also in those cases when the preparations were used in a dose of 10 mM.
    2 context sentences
    Summary · context
    The direct action of synthetic peptide preparations, analogous to thymic hormones, on the functions of phagocytic cells was studied.
    Title · context
    [Effect of thymic peptides on the functional activity of phagocytic cells of donor peripheral blood].
  5. 05LabIn vitro (cells)Activity measurement

    In donor blood cells, Thymogen stimulated monocyte hydrogen peroxide formation.

    In plain wordsIn cells from donor blood, Thymogen increased hydrogen peroxide formation in monocytes.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseMonocyte hydrogen peroxide formation
    Study

    Humann: not reported in source

    Donor peripheral blood phagocytic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 mMAs given in this study (Human).

    Source sentences

    Summary
    All preparations produced a stimulating effect on the formation of hydrogen peroxide in monocytes.
    2 context sentences
    Summary · context
    The direct action of synthetic peptide preparations, analogous to thymic hormones, on the functions of phagocytic cells was studied.
    Title · context
    [Effect of thymic peptides on the functional activity of phagocytic cells of donor peripheral blood].
  6. 06LabIn vitro (cells)Activity measurement

    In donor blood neutrophils, Thymogen increased mean DCF-DA fluorescence by 80%.

    In plain wordsIn cells from donor blood, Thymogen increased neutrophil DCF-DA fluorescence by 80%.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseNeutrophil DCF-DA fluorescence
    Study

    Humann: not reported in source

    Donor peripheral blood phagocytic cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    10 mMAs given in this study (Human).

    Measurements

    Mean DCF-DA fluorescence increase
    80%
    Thymogen

    Source sentences

    Summary
    The reaction of neutrophils was even more active: Neogen (10 mM) produced the twofold change in the intensity of the luminescence of DCF-DA) in neutrophils, Thymogen and Thynodepressin increased the average intensity of the luminescence of DCF-DA by 80% and 60%, respectively.
    2 context sentences
    Summary · context
    The direct action of synthetic peptide preparations, analogous to thymic hormones, on the functions of phagocytic cells was studied.
    Title · context
    [Effect of thymic peptides on the functional activity of phagocytic cells of donor peripheral blood].

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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