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Study · Animal study (in vivo) · rat · 2002

4 results

Epitalon influences pineal secretion in stress-exposed rats in the daytime.

Sibarov DA, Kovalenko RI, Malinin VV, Khavinson VKh

Neuro endocrinology letters1 Oct 2002Cited by 5 (Europe PMC)

PMID12500171 (opens in a new tab)PepBankPUB-12500171
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In osmotic-stress-exposed rats, intranasal Epitalon caused a slight but significant increase of C-Fos protein in pinealocytes.

    In plain wordsIn stressed rats, Epitalon given through the nose slightly raised C-Fos protein in pineal gland cells.

    Peptide
    Epitalon
    Outcome
    IncreaseC-Fos protein in pinealocytes of stress-exposed rats
    Study

    ratn: not reported in source

    Pineal gland of intact and osmotic-stress-exposed rats
    Outcome group
    Neuroprotection · Endocrine and hormones
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    A slight but significant C-Fos increase was observed only in stress-exposed pinealocytes of rats after intranasal Epitalon infusions.
    2 context sentences
    Summary · context
    Intact and osmotic-stress-exposed rats were used for the immunohistochemical detection of C-Fos protein.
    Summary · context
    All animals were intranasally administered with Epitalon, the last infusion made in two hours before the biopsy.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In intact rats, intranasal Epitalon did not significantly change C-Fos protein in pinealocytes; an increase appeared only under stress.

    In plain wordsIn rats without stress, Epitalon given through the nose did not clearly change C-Fos protein in pineal gland cells.

    Peptide
    Epitalon
    Outcome
    No significant changeC-Fos protein in pinealocytes of intact rats
    Study

    ratn: not reported in source

    Pineal gland of intact and osmotic-stress-exposed rats
    Outcome group
    Neuroprotection · Endocrine and hormones
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    A slight but significant C-Fos increase was observed only in stress-exposed pinealocytes of rats after intranasal Epitalon infusions.
    2 context sentences
    Summary · context
    Intact and osmotic-stress-exposed rats were used for the immunohistochemical detection of C-Fos protein.
    Summary · context
    All animals were intranasally administered with Epitalon, the last infusion made in two hours before the biopsy.
  3. 03AnimalAnimal study (in vivo)Other

    In stress-exposed rats, clusters of 5 10 pineal cells containing C-Fos in their cytoplasm were detected.

    In plain wordsIn stressed rats, small clusters of pineal cells containing C-Fos were seen.

    Peptide
    Epitalon
    Outcome
    Not applicableClusters of C-Fos-containing pineal cells in stress
    Study

    ratn: not reported in source

    Pineal gland of intact and osmotic-stress-exposed rats
    Outcome group
    Neuroprotection · Endocrine and hormones
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    In stress, the clusters of 5 10 cells containing C-Fos in their cytoplasm were detected.
    2 context sentences
    Summary · context
    Intact and osmotic-stress-exposed rats were used for the immunohistochemical detection of C-Fos protein.
    Summary · context
    All animals were intranasally administered with Epitalon, the last infusion made in two hours before the biopsy.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In osmotic-stress-exposed rats, intranasal Epitalon partially reduced the dilation of capillaries and pericapillary space induced by stress.

    In plain wordsIn stressed rats, Epitalon given through the nose partly reduced widening of small blood vessels in the pineal gland.

    Peptide
    Epitalon
    Outcome
    DecreaseCapillary and pericapillary dilation in pineal parenchyma
    Study

    ratn: not reported in source

    Pineal gland of intact and osmotic-stress-exposed rats
    Outcome group
    Neuroprotection · Endocrine and hormones
    Studied dose
    Dose not stated · intranasalAs given in this study (rat).

    Source sentences

    Summary
    The dilation of capillaries and pericapillary space induced by an osmotic stress was partially reduced by the intranasal infusions of Epitalon.
    2 context sentences
    Summary · context
    Intact and osmotic-stress-exposed rats were used for the immunohistochemical detection of C-Fos protein.
    Summary · context
    All animals were intranasally administered with Epitalon, the last infusion made in two hours before the biopsy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

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