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Study · Animal study (in vivo) · mouse · 2002

5 results

Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress.

Khavinson VKh, Korneva EA, Malinin VV, Rybakina EG, Pivanovich IY, Shanin SN

Neuro endocrinology letters1 Oct 2002Cited by 4 (Europe PMC)

PMID12500162 (opens in a new tab)PepBankPUB-12500162
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice under rotation stress or combined stress, Epitalon increased thymocyte proliferative activity.

    In plain wordsIn stressed mice, Epitalon increased the growth of immune thymus cells.

    Peptide
    Epitalon
    Outcome
    IncreaseThymocyte proliferative activity
    Study

    mousen: not reported in source

    Stressed and intact mice; thymocytes and cerebral cortex membranes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The investigation demonstrated that Epitalon increased thymocyte proliferative activity, both enhanced under rotation stress and suppressed under combined one.
    2 context sentences
    Summary · context
    The experiments were performed on male (CBAxC(57)BL(6))F1 mice aged 8 10 weeks.
    Summary · context
    Two models of experimental stress were used: immune-stimulatory rotation stress and immune-suppressive combined stress (cooling followed by immobilization).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, Epitalon increased the concomitant effect of IL-1beta on thymocyte proliferation.

    In plain wordsIn mice, Epitalon increased the effect of IL-1beta on immune thymus cell growth.

    Peptide
    Epitalon
    Outcome
    IncreaseIL-1beta concomitant effect on thymocyte proliferation
    Study

    mousen: not reported in source

    Stressed and intact mice; thymocytes and cerebral cortex membranes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It also increased IL-1beta concomitant effect.
    2 context sentences
    Summary · context
    The experiments were performed on male (CBAxC(57)BL(6))F1 mice aged 8 10 weeks.
    Summary · context
    Two models of experimental stress were used: immune-stimulatory rotation stress and immune-suppressive combined stress (cooling followed by immobilization).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, Epitalon effects on stress-induced changes in nSMase activity in cerebral cortex fraction P2 matched its effects on thymocyte proliferation.

    In plain wordsIn mice, Epitalon altered stress-related changes in an enzyme of the brain cortex, in line with its effect on thymus cells.

    Peptide
    Epitalon
    Outcome
    MixednSMase activity under stress-induced changes
    Study

    mousen: not reported in source

    Stressed and intact mice; thymocytes and cerebral cortex membranes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These findings corresponded to Epitalon effect on diverse stress-induced changes in nSMase activity in cerebral cortex fraction P2.
    2 context sentences
    Summary · context
    The experiments were performed on male (CBAxC(57)BL(6))F1 mice aged 8 10 weeks.
    Summary · context
    Two models of experimental stress were used: immune-stimulatory rotation stress and immune-suppressive combined stress (cooling followed by immobilization).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In intact mice, Epitalon activated nSMase in cerebral cortex membranes.

    In plain wordsIn mice without stress, Epitalon raised the activity of an enzyme in brain cortex membranes.

    Peptide
    Epitalon
    Outcome
    IncreasenSMase activity in cerebral cortex membranes of intact mice
    Study

    mousen: not reported in source

    Stressed and intact mice; thymocytes and cerebral cortex membranes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epitalon activated nSMase in the cerebral cortex membranes of intact mice
    2 context sentences
    Summary · context
    The experiments were performed on male (CBAxC(57)BL(6))F1 mice aged 8 10 weeks.
    Summary · context
    Two models of experimental stress were used: immune-stimulatory rotation stress and immune-suppressive combined stress (cooling followed by immobilization).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In intact mice, Epitalon increased the stimulatory effect of IL-1beta on nSMase activity.

    In plain wordsIn mice, Epitalon strengthened the effect of IL-1beta on an enzyme in brain cortex membranes.

    Peptide
    Epitalon
    Outcome
    IncreaseIL-1beta stimulatory effect on nSMase activity
    Study

    mousen: not reported in source

    Stressed and intact mice; thymocytes and cerebral cortex membranes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    and increased IL-1beta stimulatory effect on the enzyme activity.
    2 context sentences
    Summary · context
    The experiments were performed on male (CBAxC(57)BL(6))F1 mice aged 8 10 weeks.
    Summary · context
    Two models of experimental stress were used: immune-stimulatory rotation stress and immune-suppressive combined stress (cooling followed by immobilization).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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