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Study · Animal study (in vivo) · rat · 2002

4 results

Modulation of melanocortin-induced changes in spinal nociception by mu-opioid receptor agonist and antagonist in neuropathic rats.

Starowicz K, Przewlocki R, Gispen WH, Przewlocka B

Neuroreport1 Dec 2002Cited by 39 (Europe PMC)

PMID12499847 (opens in a new tab)DOI10.1097/00001756-200212200-00015 (opens in a new tab)PepBankPUB-12499847
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with neuropathic pain, intrathecal MTII increased sensitivity to tactile stimulation.

    In plain wordsIn rats with nerve injury, MTII given into the spinal canal increased sensitivity to touch.

    Peptide
    Melanotan II
    Outcome
    IncreaseTactile sensitivity (allodynia)
    Study

    ratn: not reported in source

    Rats with chronic constriction injury of the sciatic nerve (neuropathic pain)
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Administration of melanocortin receptor agonist, melanotan-II (MTII) increased the sensitivity to tactile and cold stimulation.
    1 context sentence
    Summary · context
    Neuropathic pain was induced by chronic constriction injury (CCI) of the right sciatic nerve in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with neuropathic pain, intrathecal MTII increased sensitivity to cold stimulation.

    In plain wordsIn rats with nerve injury, MTII given into the spinal canal increased sensitivity to cold.

    Peptide
    Melanotan II
    Outcome
    IncreaseCold sensitivity (allodynia)
    Study

    ratn: not reported in source

    Rats with chronic constriction injury of the sciatic nerve (neuropathic pain)
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (rat).

    Source sentences

    Summary
    Administration of melanocortin receptor agonist, melanotan-II (MTII) increased the sensitivity to tactile and cold stimulation.
    1 context sentence
    Summary · context
    Neuropathic pain was induced by chronic constriction injury (CCI) of the right sciatic nerve in rats.

Studies that did not test the peptide alone2

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 03AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In rats with neuropathic pain, blockade of the mu-opioid receptor by cyprodime enhanced the pronociceptive action of MTII (MTII was the challenge).

    In plain wordsIn rats with nerve injury, blocking the mu-opioid receptor made the pain-increasing action of MTII stronger.

    Peptide
    Melanotan II
    Outcome
    IncreaseEffect of cyprodime on MTII pronociceptive action
    Study

    ratn: not reported in source

    Rats with chronic constriction injury of the sciatic nerve (neuropathic pain)
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    Moreover, we demonstrated that the selective blockade of mu-opioid receptor by cyprodime (CP) enhanced antiallodynic effect of SHU9119 as well as pronociceptive action of MTII
    1 context sentence
    Summary · context
    Neuropathic pain was induced by chronic constriction injury (CCI) of the right sciatic nerve in rats.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

  2. 04AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In rats with neuropathic pain, the mu-opioid agonist DAMGO reversed the proallodynic effect of MTII (MTII was the challenge).

    In plain wordsIn rats with nerve injury, the opioid DAMGO reversed the pain-increasing effect of MTII.

    Peptide
    Melanotan II
    Outcome
    DecreaseEffect of DAMGO on MTII proallodynic effect
    Study

    ratn: not reported in source

    Rats with chronic constriction injury of the sciatic nerve (neuropathic pain)
    Comparator
    MTII alone
    Outcome group
    Pain · Nervous system and cognition

    Source sentences

    Summary
    DAMGO also reversed the proallodynic effect of melanocortin receptor agonist, MTII.
    1 context sentence
    Summary · context
    Neuropathic pain was induced by chronic constriction injury (CCI) of the right sciatic nerve in rats.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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