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Study · Animal study (in vivo) · rat · 2003

4 results

Effects of AICAR and exercise on insulin-stimulated glucose uptake, signaling, and GLUT-4 content in rat muscles.

Jessen N, Pold R, Buhl ES, Jensen LS, Schmitz O, Lund S

Journal of applied physiology (Bethesda, Md. : 1985)20 Dec 2002Cited by 126 (Europe PMC)

PMID12496137 (opens in a new tab)DOI10.1152/japplphysiol.00250.2002 (opens in a new tab)PepBankPUB-12496137
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In Wistar rats, AICAR increased insulin-stimulated muscle glucose transport versus sedentary controls, most markedly in muscles rich in type IIb fibers.

    In plain wordsIn rats, AICAR increased insulin-stimulated muscle glucose transport compared with sedentary controls, most in muscles rich in type IIb fibers.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseInsulin-stimulated glucose transport
    Study

    ratn: not reported in source

    Wistar rat skeletal muscles
    Comparator
    sedentary controls
    Outcome group
    Glycemic control · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Both exercised and AICAR-injected animals displayed a fiber-type-specific increase in glucose transport with the most marked increase in muscles with a high content of type IIb fibers.
    1 context sentence
    Summary · context
    Wistar rats were allocated into three groups: an exercise group trained on treadmill for 5 days, an AICAR group exposed to daily subcutaneous injections of AICAR, and a sedentary control group.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In Wistar rats, the AICAR-associated increase in glucose transport accompanied increased muscle GLUT-4 expression.

    In plain wordsIn rats, AICAR increased muscle GLUT-4 expression compared with sedentary controls.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreaseGLUT-4 expression
    Study

    ratn: not reported in source

    Wistar rat skeletal muscles
    Comparator
    sedentary controls
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    This increase was accompanied by a concomitant increase in GLUT-4 expression.
    2 context sentences
    Summary · context
    Both exercised and AICAR-injected animals displayed a fiber-type-specific increase in glucose transport with the most marked increase in muscles with a high content of type IIb fibers.
    Summary · context
    Wistar rats were allocated into three groups: an exercise group trained on treadmill for 5 days, an AICAR group exposed to daily subcutaneous injections of AICAR, and a sedentary control group.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In Wistar rats, AICAR enhanced insulin signaling assessed by phosphatidylinositol 3-kinase activity without fiber-type specificity.

    In plain wordsIn rats, AICAR increased phosphatidylinositol 3-kinase activity compared with sedentary controls, without dependence on muscle fiber type.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePhosphatidylinositol 3-kinase activity
    Study

    ratn: not reported in source

    Wistar rat skeletal muscles
    Comparator
    sedentary controls
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Insulin signaling as assessed by phosphatidylinositol 3-kinase and PKB/Akt activity was enhanced only after AICAR administration and in a non-fiber-type-specific manner.
    1 context sentence
    Summary · context
    Wistar rats were allocated into three groups: an exercise group trained on treadmill for 5 days, an AICAR group exposed to daily subcutaneous injections of AICAR, and a sedentary control group.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In Wistar rats, AICAR enhanced insulin signaling assessed by PKB/Akt activity without fiber-type specificity.

    In plain wordsIn rats, AICAR increased PKB/Akt activity compared with sedentary controls, without dependence on muscle fiber type.

    Peptide
    AICAR (acadesine)
    Outcome
    IncreasePKB/Akt activity
    Study

    ratn: not reported in source

    Wistar rat skeletal muscles
    Comparator
    sedentary controls
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    Insulin signaling as assessed by phosphatidylinositol 3-kinase and PKB/Akt activity was enhanced only after AICAR administration and in a non-fiber-type-specific manner.
    1 context sentence
    Summary · context
    Wistar rats were allocated into three groups: an exercise group trained on treadmill for 5 days, an AICAR group exposed to daily subcutaneous injections of AICAR, and a sedentary control group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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