Comparative in vitro activity of five cathelicidin-derived synthetic peptides against Leptospira, Borrelia and Treponema pallidum.

Sambri V, Marangoni A, Giacani L, Gennaro R, Murgia R, Cevenini R, Cinco M

The Journal of antimicrobial chemotherapy1 Dec 2002Cited by 46 (Europe PMC)

PMID12461010DOI10.1093/jac/dkf220PepBankPUB-12461010

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In vitro, LL‑37 had a MIC of 449.4 mg/L against Treponema pallidum, the highest value among the five cathelicidin-derived peptides.
In plain wordsIn lab tests, LL‑37 needed a high dose, 449.4 mg/L, to stop Treponema pallidum from moving.
Peptide
LL-37
Outcome
Not applicableMIC against Treponema pallidum
Study
n: not reported in source
spirochaete cultures
Outcome group
Infection and antimicrobial activity · Infection
Studied dose
Dose not stated · 2 hAs given in this study.
Measurements
MIC
449.4 mg/L
T. pallidum subsp. pallidum
Source sentences
Summary
The MIC values of synthetic peptides for T. pallidum ranged between 32.3 mg/L for PG-1 and 449.4 mg/L for LL-37.
1 context sentence(design, population, supporting numbers)
Summary · context
The MIC of individual peptides was defined as the lowest concentration able to inhibit the motility of spirochaetes after 2 h of incubation, as detected by dark-field microscopy.
Report a problemFND-1246101001

Studies that did not test the peptide alone4

In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking LL-37.

02LabNot a test of LL-37 aloneIn vitro (cells)Activity measurement
In vitro, the MICs of the remaining synthetic cathelicidin peptides, a pool that includes LL‑37, against Leptospira interrogans ranged from 4.3 to 224 mg/L.
In plain wordsIn lab tests, three cathelicidin-derived peptides including LL‑37 had MICs of 4.3 to 224 mg/L against Leptospira. No separate LL‑37 value is given.
Peptide
LL-37
Outcome
Not applicableMIC of the remaining peptides against Leptospira interrogans (pooled)
Study
n: not reported in source
spirochaete cultures
Outcome group
Infection and antimicrobial activity · Infection
Measurements
MIC range
4.3 to 224 mg/L
Leptospira interrogans
Source sentences
Summary
Of the five cathelicidin-derived peptides, SMAP-29 from sheep and BMAP-28 from cattle were the most active against L. interrogans serovars, with MIC values varying between 3 and 51 mg/L, depending on the strains. The MICs of the remaining synthetic peptides ranged between 4.3 and 224 mg/L.
1 context sentence(design, population, supporting numbers)
Summary · context
The MIC of individual peptides was defined as the lowest concentration able to inhibit the motility of spirochaetes after 2 h of incubation, as detected by dark-field microscopy.
In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.
Report a problemFND-1246101002
03LabNot a test of LL-37 aloneIn vitro (cells)Activity measurement
In vitro, the MICs of all five cathelicidin-derived peptides, including LL‑37, against Borrelia strains ranged from 307 to 449.4 mg/L.
In plain wordsIn lab tests, five cathelicidin-derived peptides including LL‑37 had MICs of 307 to 449.4 mg/L against Borrelia. No separate LL‑37 value is given.
Peptide
LL-37
Outcome
Not applicableMIC of all peptides against Borrelia (pooled)
Study
n: not reported in source
spirochaete cultures
Outcome group
Infection and antimicrobial activity · Infection
Measurements
MIC range
307 to 449.4 mg/L
Borrelia strains
Source sentences
Summary
The MICs of all cathelicidin-derived peptides tested for Borrelia strains ranged between 307 and 449.4 mg/L.
1 context sentence(design, population, supporting numbers)
Summary · context
The MIC of individual peptides was defined as the lowest concentration able to inhibit the motility of spirochaetes after 2 h of incubation, as detected by dark-field microscopy.
In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.
Report a problemFND-1246101003
04LabNot a test of LL-37 aloneIn vitro (cells)Activity measurement
In vitro, the activity of the pooled cathelicidin-derived peptides on spirochaete motility was dose- and time-dependent.
In plain wordsIn lab tests, the five peptides, LL‑37 among them, stopped spirochaetes from moving more with higher dose and longer time.
Peptide
LL-37
Outcome
Not applicableDose and time dependence of motility inhibition (pooled)
Study
n: not reported in source
spirochaete cultures
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
The activity of the peptides on the motility of spirochaetes was both dose- and time-dependent.
1 context sentence(design, population, supporting numbers)
Summary · context
The MIC of individual peptides was defined as the lowest concentration able to inhibit the motility of spirochaetes after 2 h of incubation, as detected by dark-field microscopy.
In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.
Report a problemFND-1246101004
05LabNot a test of LL-37 aloneIn vitro (cells)Activity measurement
In vitro, the MBC values of the pooled cathelicidin-derived peptides were the same as their MIC values.
In plain wordsIn lab tests, the killing doses of the five peptides, LL‑37 among them, were the same as the doses that stopped movement.
Peptide
LL-37
Outcome
Not applicableMBC compared with MIC (pooled)
Study
n: not reported in source
spirochaete cultures
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
The MBC values of the peptides were the same as the MIC values.
1 context sentence(design, population, supporting numbers)
Summary · context
The MIC of individual peptides was defined as the lowest concentration able to inhibit the motility of spirochaetes after 2 h of incubation, as detected by dark-field microscopy.
In this study, LL-37 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking LL-37.
Report a problemFND-1246101005

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
11 Oct 2026, 00:50 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.