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Study · Animal study (in vivo) · rat · 2002

2 results

Delta sleep-inducing peptide blocks excitatory effects of glutamate on rat brain neurons.

Umriukhin PE

Bulletin of experimental biology and medicine1 Jul 2002Cited by 4 (Europe PMC)

PMID12459854 (opens in a new tab)DOI10.1023/a:1020679815690 (opens in a new tab)PepBankPUB-12459854
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, microiontophoresis of DSIP primarily activated neurons in the dorsal hippocampus, anteroventral thalamic nucleus, lateral hypothalamus and sensorimotor cortex.

    In plain wordsIn rats, DSIP applied next to brain cells mainly raised the activity of neurons in several brain areas.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseNeuronal activity in hippocampus, thalamus, hypothalamus and cortex
    Study

    ratn: not reported in source

    rat brain neurons, microiontophoresis
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Source sentences

    Summary
    Microiontophoresis of delta sleep-inducing peptide primarily activated neurons in the dorsal hippocampus, anteroventral thalamic nucleus, lateral hypothalamus, and sensorimotor cortex.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, preliminary microiontophoresis of DSIP blocked the excitatory effect of glutamate on neurons in these brain structures.

    In plain wordsIn rats, DSIP applied beforehand blocked the activating effect of glutamate on brain neurons.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseGlutamate-induced neuronal excitation
    Study

    ratn: not reported in source

    rat brain neurons, microiontophoresis
    Comparator
    Glutamate alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · microiontophoresisAs given in this study (rat).

    Source sentences

    Summary
    Microiontophoretic administration of glutamate markedly enhanced neuronal activity, while preliminary microionophoresis of delta sleep-inducing peptide blocked the excitatory effect of glutamate on neurons in these brain structures.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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