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Study · Non-randomized trial · n = 6 · 2002

3 results

Ghrelin-induced GH secretion in normal subjects is partially resistant to homologous desensitization by GH-releasing peptide-6.

Micic D, Macut D, Sumarac-Dumanovic M, Kendereski A, Popovic V, Deghenghi R, Dieguez C, Casanueva FF

European journal of endocrinology1 Dec 2002Cited by 7 (Europe PMC)

PMID12457451 (opens in a new tab)DOI10.1530/eje.0.1470761 (opens in a new tab)PepBankPUB-12457451
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In six normal subjects, GHRP‑6 at time 0 induced a GH peak of 18.4 microg/l.

    In plain wordsIn six healthy people, GHRP‑6 raised growth hormone to a peak of 18.4 microg/l.

    Peptide
    GHRP-6
    Outcome
    IncreaseGH peak after GHRP-6
    Study

    n = 6

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg · intravenousAs given in this study (human).

    Measurements

    GH peak
    18.4 microg/l
    GHRP-6 at time 0

    Source sentences

    Summary
    On the last testing day, GHRP-6 at time 0 induced a GH peak of 18.4+/-5.9 microg/l and ghrelin 120 min later a peak of 19.8+/-2.9 microg/l.
    2 context sentences
    Summary · context
    Ghrelin, GHRH and GHRP-6 were always administered at 1 microg/kg i.v., and plasma GH was measured.
    Summary · context
    Six normal subjects participated in the study after providing informed consent, and each was assessed on three different testing days, at least 1 week apart.
  2. 02HumanNon-randomized trialMechanism

    In six normal subjects, ghrelin-induced GH secretion 120 min after GHRP‑6 was significantly lower than after saline, which shows partial homologous desensitization by GHRP‑6.

    In plain wordsIn six healthy people, GHRP‑6 partly reduced the growth hormone response to ghrelin given 120 minutes later, compared with saline.

    Peptide
    GHRP-6
    Outcome
    DecreaseGhrelin-induced GH secretion after GHRP-6 pretreatment
    Study

    n = 6

    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg · intravenousAs given in this study (human).

    Measurements

    Ghrelin-induced GH peak
    19.8 microg/l
    after GHRP-6
    Ghrelin-induced GH peak
    39.9 microg/l
    after saline

    Source sentences

    Summary
    The ghrelin-mediated GH secretion after GHRP-6 was significantly lower than the GH elicited by ghrelin when the preceding administration was saline.
    4 context sentences
    Summary · context
    On the last testing day, GHRP-6 at time 0 induced a GH peak of 18.4+/-5.9 microg/l and ghrelin 120 min later a peak of 19.8+/-2.9 microg/l.
    Summary · context
    Saline did not modify peak GH (means+/-s.e.) values (1.5+/-0.6 microg/l), and ghrelin administered 120 min later induced a significant GH rise (39.9+/-2.8 microg/l).
    Summary · context
    Ghrelin, GHRH and GHRP-6 were always administered at 1 microg/kg i.v., and plasma GH was measured.
    Summary · context
    Six normal subjects participated in the study after providing informed consent, and each was assessed on three different testing days, at least 1 week apart.
  3. 03HumanNon-randomized trialEfficacy outcome

    In six normal subjects, GHRP‑6 was a less potent GH stimulus than ghrelin, calculated at equal mass doses or in molecular terms.

    In plain wordsIn six healthy people, ghrelin looked like a stronger growth hormone stimulus than GHRP‑6.

    Peptide
    GHRP-6
    Outcome
    DecreaseRelative GH-releasing potency of GHRP-6 versus ghrelin
    Study

    n = 6

    Comparator
    Ghrelin
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microg/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Calculated at equal mass doses or in molecular terms, ghrelin appears to be a more potent stimulus than GHRP-6 and GHRH.
    2 context sentences
    Summary · context
    Ghrelin, GHRH and GHRP-6 were always administered at 1 microg/kg i.v., and plasma GH was measured.
    Summary · context
    Six normal subjects participated in the study after providing informed consent, and each was assessed on three different testing days, at least 1 week apart.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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