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Study · Animal study (in vivo) · rat · 2002

5 results

[Optimizing action of synthetic peptide Selank on active avoidance conditioning test in rats].

Kozlovskiĭ II, Danchev ND

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova1 Sept 2002Cited by 1 (Europe PMC)

PMID12449836 (opens in a new tab)PepBankPUB-12449836
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with initially low learning ability, Selank significantly improved learning in the active avoidance test, even after a single dose on the first day.

    In plain wordsIn rats that learned poorly at first, Selank improved learning in an avoidance test, even after one dose.

    Peptide
    Selank
    Outcome
    IncreaseLearning in rats with low learning ability after a single dose
    Study

    ratn: not reported in source

    active avoidance conditioning test
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 micrograms/kg · single administration on day 1As given in this study (rat).

    Source sentences

    Summary
    Selank was found to significantly improve learning in rats with low level ability even after a single administration on the first day of training session.
    2 context sentences
    Summary · context
    The action of a synthetic peptide Selank on learning and memory in active avoidance conditioning test was studied in rats with initially low learning ability and normal animals.
    Summary · context
    The effect of Selank (300 micrograms/kg) was compared to that of Pyracetam (400 mg/kg).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    With repeated Selank treatment, the total number of reactions in the active avoidance test increased in rats.

    In plain wordsIn rats, repeated Selank treatment increased the total number of reactions in an avoidance learning test.

    Peptide
    Selank
    Outcome
    IncreaseTotal number of reactions with repeated Selank treatment
    Study

    ratn: not reported in source

    active avoidance conditioning test
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 micrograms/kg · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    The effect progressively increased with repeated Selank treatment: the total numbers of reactions and correct reactions increased, and the number of errors decreased (p < 0.05).
    2 context sentences
    Summary · context
    The action of a synthetic peptide Selank on learning and memory in active avoidance conditioning test was studied in rats with initially low learning ability and normal animals.
    Summary · context
    The effect of Selank (300 micrograms/kg) was compared to that of Pyracetam (400 mg/kg).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    With repeated Selank treatment, the number of correct reactions in the active avoidance test increased in rats.

    In plain wordsIn rats, repeated Selank treatment increased the number of correct reactions in an avoidance learning test.

    Peptide
    Selank
    Outcome
    IncreaseNumber of correct reactions with repeated Selank treatment
    Study

    ratn: not reported in source

    active avoidance conditioning test
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 micrograms/kg · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    The effect progressively increased with repeated Selank treatment: the total numbers of reactions and correct reactions increased, and the number of errors decreased (p < 0.05).
    2 context sentences
    Summary · context
    The action of a synthetic peptide Selank on learning and memory in active avoidance conditioning test was studied in rats with initially low learning ability and normal animals.
    Summary · context
    The effect of Selank (300 micrograms/kg) was compared to that of Pyracetam (400 mg/kg).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    With repeated Selank treatment, the number of errors in the active avoidance test decreased in rats.

    In plain wordsIn rats, repeated Selank treatment reduced the number of errors in an avoidance learning test.

    Peptide
    Selank
    Outcome
    DecreaseNumber of errors with repeated Selank treatment
    Study

    ratn: not reported in source

    active avoidance conditioning test
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 micrograms/kg · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    The effect progressively increased with repeated Selank treatment: the total numbers of reactions and correct reactions increased, and the number of errors decreased (p < 0.05).
    2 context sentences
    Summary · context
    The action of a synthetic peptide Selank on learning and memory in active avoidance conditioning test was studied in rats with initially low learning ability and normal animals.
    Summary · context
    The effect of Selank (300 micrograms/kg) was compared to that of Pyracetam (400 mg/kg).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In normal rats, the effect of Selank in the active avoidance test was maximal on the third day of treatment and training.

    In plain wordsIn normal rats, the effect of Selank in an avoidance test was largest on the third day.

    Peptide
    Selank
    Outcome
    Direction not reportedLearning in normal rats over the treatment days
    Study

    ratn: not reported in source

    active avoidance conditioning test
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    300 micrograms/kg · 4 daysAs given in this study (rat).

    Source sentences

    Summary
    In normal rats, the effect was maximal on the third day of treatment and training, i.e., after the completed initial consolidation.
    2 context sentences
    Summary · context
    The action of a synthetic peptide Selank on learning and memory in active avoidance conditioning test was studied in rats with initially low learning ability and normal animals.
    Summary · context
    The effect of Selank (300 micrograms/kg) was compared to that of Pyracetam (400 mg/kg).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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