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Study · In vitro (cells) · rat · 2002

1 result

Epidermal growth factor-induced activation of the insulin-like growth factor I receptor in rat hepatocytes.

Hallak H, Moehren G, Tang J, Kaou M, Addas M, Hoek JB, Rubin R

Hepatology (Baltimore, Md.)1 Dec 2002Cited by 15 (Europe PMC)

PMID12447877 (opens in a new tab)DOI10.1053/jhep.2002.37138 (opens in a new tab)PepBankPUB-12447877
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In isolated rat hepatocytes, des(1‑3)IGF-I induced IGF-IR phosphorylation whereas IGF-I did not activate the receptor.

    In plain wordsIn cells from rat livers, des(1‑3)IGF-I activated IGF receptor phosphorylation whereas IGF-I did not activate the receptor.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGF-IR phosphorylation
    Study

    ratn: not reported in source

    freshly isolated hepatocytes
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, des(1-3)IGF-I, which weakly binds IGF binding protein-3 (IGFBP-3), induced IGF-IR phosphorylation.
    2 context sentences
    Summary · context
    IGF-I did not activate the IGF-IR.
    Summary · context
    The dynamics of IGF-I receptor (IGF-IR) activation were examined in freshly isolated rat hepatocytes.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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