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Study · In vitro (cells) · mouse · 2002

4 results

In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes.

Kazakova TB, Barabanova SV, Khavinson VKh, Glushikhina MS, Parkhomenko EP, Malinin VV, Korneva EA

Bulletin of experimental biology and medicine1 Jun 2002Cited by 3 (Europe PMC)

PMID12447482 (opens in a new tab)DOI10.1023/a:1020210615148 (opens in a new tab)PepBankPUB-12447482
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In splenocytes from CBA mice, Epithalon was among the most potent peptides for interleukin-2 mRNA synthesis, while Cortagen had a less pronounced effect.

    In plain wordsIn lab tests on mouse immune cells, Epithalon raised interleukin-2 gene activity more strongly than Cortagen.

    Peptide
    Epitalon
    Outcome
    IncreasePotency for interleukin-2 mRNA synthesis versus Cortagen
    Study

    mousen: not reported in source

    Splenocytes from CBA mice
    Comparator
    Cortagen
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.
  2. 02LabIn vitro (cells)Mechanism

    In CBA mouse splenocytes, Cortagen activated interleukin-2 mRNA synthesis without specific inductors.

    In plain wordsIn cells from mice, Cortagen increased interleukin-2 mRNA synthesis without specific inductors.

    Peptide
    Cortagen (AEDP)
    Outcome
    IncreaseInterleukin-2 mRNA synthesis without specific inductors
    Study

    mousen: not reported in source

    Splenocytes from CBA mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors.
  3. 03LabIn vitro (cells)Mechanism

    In mouse splenocytes, Cortagen had a less pronounced effect on interleukin-2 mRNA synthesis than Vilon.

    In plain wordsIn cells from mice, Cortagen increased interleukin-2 mRNA synthesis less than Vilon.

    Peptide
    Cortagen (AEDP)
    Outcome
    DecreaseInterleukin-2 mRNA synthesis versus Vilon
    Study

    mousen: not reported in source

    Splenocytes from CBA mice
    Comparator
    Vilon
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.
    1 context sentence
    Summary · context
    Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors.
  4. 04LabIn vitro (cells)Mechanism

    In mouse splenocytes, Cortagen had a less pronounced effect on interleukin-2 mRNA synthesis than Epithalon.

    In plain wordsIn cells from mice, Cortagen increased interleukin-2 mRNA synthesis less than Epithalon.

    Peptide
    Cortagen (AEDP)
    Outcome
    DecreaseInterleukin-2 mRNA synthesis versus Epithalon
    Study

    mousen: not reported in source

    Splenocytes from CBA mice
    Comparator
    Epithalon
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.
    1 context sentence
    Summary · context
    Synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) in vitro activated interleukin-2 mRNA synthesis in splenocytes from CBA mice in the absence of specific inductors.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 10Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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