Possible mechanism underlying the effect of Semax on the formation of indomethacin-induced ulcers in rats.

Zhuikova SE, Sergeev VI, Samonina GE, Myasoedov NF

Bulletin of experimental biology and medicine1 Jun 2002Cited by 5 (Europe PMC)

PMID12447470DOI10.1023/a:1020285909696PepBankPUB-12447470

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with indomethacin-induced ulcers, intraperitoneal Semax produced a protective effect.
In plain wordsIn rats with ulcers caused by indomethacin, Semax injected into the abdomen had a protective effect.
Peptide
Semax
Outcome
DecreaseIndomethacin-induced gastric ulcers
Study
ratn: not reported in source
Indomethacin-induced ulcers
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
50 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers.
Report a problemFND-1244747001
02AnimalAnimal study (in vivo)Mechanism
In narcotized rats, Semax had no effect on basal blood flow in the stomach.
In plain wordsIn anaesthetized rats, Semax did not change normal blood flow in the stomach.
Peptide
Semax
Outcome
No significant changeBasal gastric blood flow
Study
ratn: not reported in source
Narcotized rats
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
50 mg/kgAs given in this study (rat).
Source sentences
Summary
Experiments on narcotized rats showed that Semax in the studied dose had no effect on basal blood flow in the stomach, but prevented reduction of blood flow induced by indomethacin.
1 context sentence(design, population, supporting numbers)
Summary · context
Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers.
Report a problemFND-1244747002
03AnimalAnimal study (in vivo)Mechanism
In narcotized rats, Semax prevented the reduction of stomach blood flow induced by indomethacin.
In plain wordsIn anaesthetized rats, Semax prevented the drop in stomach blood flow caused by indomethacin.
Peptide
Semax
Outcome
IncreaseIndomethacin-induced reduction of gastric blood flow
Study
ratn: not reported in source
Narcotized rats
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
50 mg/kgAs given in this study (rat).
Source sentences
Summary
Experiments on narcotized rats showed that Semax in the studied dose had no effect on basal blood flow in the stomach, but prevented reduction of blood flow induced by indomethacin.
1 context sentence(design, population, supporting numbers)
Summary · context
Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers.
Report a problemFND-1244747003

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 19:08 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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