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Study · Observational study · n = 13 · 2002

5 results

Maintenance of spermatogenesis in hypogonadotropic hypogonadal men with human chorionic gonadotropin alone.

Depenbusch M, von Eckardstein S, Simoni M, Nieschlag E

European journal of endocrinology1 Nov 2002Cited by 67 (Europe PMC)

PMID12444893 (opens in a new tab)DOI10.1530/eje.0.1470617 (opens in a new tab)PepBankPUB-12444893
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanObservational studyEfficacy outcome

    In hypogonadotropic men, sperm counts gradually decreased after 12 Months of hCG alone following spermatogenesis induction.

    In plain wordsIn hypogonadotropic men, hCG alone was linked to lower sperm counts than after sperm production induction.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    DecreaseSperm counts
    Study

    n = 13

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 12 MonthsAs given in this study (human).

    Source sentences

    Summary
    After 12 Months under hCG alone, sperm counts decreased gradually but remained present in all patients except one who became azoospermic.
    2 context sentences
    Summary · context
    13 patients with gonadotropin deficiency due to idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome or pituitary insufficiency were analyzed retrospectively.
    Summary · context
    After successful induction of spermatogenesis they were treated with hCG alone for maintenance of secondary sex characteristics and in order to check whether sperm production could be maintained by hCG alone.
  2. 02HumanObservational studyEfficacy outcome

    In hypogonadotropic men, testicular volume decreased slightly during hCG alone to 87% of the volume achieved with hCG/hMG.

    In plain wordsIn hypogonadotropic men, hCG alone was linked to slightly lower testicular volume than after hCG/hMG.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    DecreaseTesticular volume
    Study

    n = 13

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 3-24 MonthsAs given in this study (human).

    Measurements

    testicular volume relative to volume achieved with hCG/hMG
    87%
    after hCG alone

    Source sentences

    Summary
    Testicular Volume decreased only slightly and reached 87% of the Volume achieved with hCG/hMG.
    2 context sentences
    Summary · context
    13 patients with gonadotropin deficiency due to idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome or pituitary insufficiency were analyzed retrospectively.
    Summary · context
    After successful induction of spermatogenesis they were treated with hCG alone for maintenance of secondary sex characteristics and in order to check whether sperm production could be maintained by hCG alone.
  3. 03HumanObservational studyEfficacy outcome

    In hypogonadotropic men, hCG alone suppressed FSH below the assay detection limit.

    In plain wordsIn hypogonadotropic men, hCG alone was linked to FSH levels below the test detection limit.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    DecreaseFSH levels
    Study

    n = 13

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 3-24 MonthsAs given in this study (human).

    Source sentences

    Summary
    During treatment with hCG alone, FSH and LH levels were suppressed to below the detection limit of the assay.
    2 context sentences
    Summary · context
    13 patients with gonadotropin deficiency due to idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome or pituitary insufficiency were analyzed retrospectively.
    Summary · context
    After successful induction of spermatogenesis they were treated with hCG alone for maintenance of secondary sex characteristics and in order to check whether sperm production could be maintained by hCG alone.
  4. 04HumanObservational studyEfficacy outcome

    In hypogonadotropic men, hCG alone suppressed LH below the assay detection limit.

    In plain wordsIn hypogonadotropic men, hCG alone was linked to LH levels below the test detection limit.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    DecreaseLH levels
    Study

    n = 13

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 3-24 MonthsAs given in this study (human).

    Source sentences

    Summary
    During treatment with hCG alone, FSH and LH levels were suppressed to below the detection limit of the assay.
    2 context sentences
    Summary · context
    13 patients with gonadotropin deficiency due to idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome or pituitary insufficiency were analyzed retrospectively.
    Summary · context
    After successful induction of spermatogenesis they were treated with hCG alone for maintenance of secondary sex characteristics and in order to check whether sperm production could be maintained by hCG alone.
  5. 05HumanObservational studyEfficacy outcome

    After 12 Months of hCG alone following spermatogenesis induction, one hypogonadotropic patient became azoospermic.

    In plain wordsAfter hCG alone following sperm production induction, one hypogonadotropic patient had no sperm.

    Peptide
    hCG (human chorionic gonadotropin)
    Outcome
    Not applicableAzoospermia during hCG maintenance
    Study

    n = 13

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · 12 MonthsAs given in this study (human).

    Measurements

    Patients becoming azoospermic
    1 patient
    after 12 Months under hCG alone following spermatogenesis induction

    Source sentences

    Summary
    After 12 Months under hCG alone, sperm counts decreased gradually but remained present in all patients except one who became azoospermic.
    2 context sentences
    Summary · context
    13 patients with gonadotropin deficiency due to idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome or pituitary insufficiency were analyzed retrospectively.
    Summary · context
    After successful induction of spermatogenesis they were treated with hCG alone for maintenance of secondary sex characteristics and in order to check whether sperm production could be maintained by hCG alone.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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