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Study · Animal study (in vivo) · mouse · 2002

4 results

Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions.

Sokolov OY, Meshavkin VK, Kost NV, Zozulya AA

Bulletin of experimental biology and medicine1 Feb 2002Cited by 6 (Europe PMC)

PMID12432865 (opens in a new tab)DOI10.1023/a:1015582302311 (opens in a new tab)PepBankPUB-12432865
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In BALB/c mice, Selank at 100 micrograms/kg produced an anxiolytic effect in the open-field test.

    In plain wordsIn BALB/c mice, Selank reduced anxiety-like behaviour in an open-field test.

    Peptide
    Selank
    Outcome
    DecreaseAnxiety-like behavior in open-field test, BALB/c mice
    Study

    mousen: not reported in source

    BALB/c mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    100 micrograms/kgAs given in this study (mouse).

    Source sentences

    Summary
    Selank in a dose of 100 micrograms/kg produced an anxiolytic effect in the open-field test and increased the half-life of plasma leu-enkephalin in BALB/c mice,
  2. 02AnimalAnimal study (in vivo)Mechanism

    In BALB/c mice, Selank at 100 micrograms/kg increased the half-life of plasma leu-enkephalin.

    In plain wordsIn BALB/c mice, Selank made the body's pain-related enkephalin last longer in blood plasma.

    Peptide
    Selank
    Outcome
    IncreasePlasma leu-enkephalin half-life, BALB/c mice
    Study

    mousen: not reported in source

    BALB/c mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 micrograms/kgAs given in this study (mouse).

    Source sentences

    Summary
    Selank in a dose of 100 micrograms/kg produced an anxiolytic effect in the open-field test and increased the half-life of plasma leu-enkephalin in BALB/c mice,
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In C57Bl/6 mice, Selank at 100 micrograms/kg had no effect on behavioral reactions.

    In plain wordsIn C57Bl/6 mice, Selank did not change behaviour.

    Peptide
    Selank
    Outcome
    No significant changeBehavioral reactions, C57Bl/6 mice
    Study

    mousen: not reported in source

    C57Bl/6 mice
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    100 micrograms/kgAs given in this study (mouse).

    Source sentences

    Summary
    but had no effect on behavioral reactions and enkephalinase activities in C57Bl/6 mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In C57Bl/6 mice, Selank at 100 micrograms/kg had no effect on plasma enkephalinase activities.

    In plain wordsIn C57Bl/6 mice, Selank did not change the activity of enzymes that break down enkephalin.

    Peptide
    Selank
    Outcome
    No significant changeEnkephalinase activity, C57Bl/6 mice
    Study

    mousen: not reported in source

    C57Bl/6 mice
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 micrograms/kgAs given in this study (mouse).

    Source sentences

    Summary
    but had no effect on behavioral reactions and enkephalinase activities in C57Bl/6 mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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