Skip to content

Study · Animal study (in vivo) · dog · 2002

5 results

Effects of growth hormone-releasing peptides in healthy dogs and in dogs with pituitary-dependent hyperadrenocorticism.

Bhatti SF, De Vliegher SP, Van Ham L, Kooistra HS

Molecular and cellular endocrinology1 Nov 2002Cited by 13 (Europe PMC)

PMID12431802 (opens in a new tab)DOI10.1016/s0303-7207(02)00293-9 (opens in a new tab)PepBankPUB-12431802
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In dogs with pituitary-dependent hyperadrenocorticism, GHRP‑6-induced GH release was significantly lower than in healthy dogs.

    In plain wordsIn dogs with pituitary-dependent hyperadrenocorticism, GHRP‑6 released less growth hormone than in healthy dogs.

    Peptide
    GHRP-6
    Outcome
    DecreaseGHRP-6-induced GH release in dogs with PDH versus healthy dogs
    Study

    dogn = 15

    Comparator
    Healthy dogs
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the dogs with PDH, the GHRP-6-induced release of GH was significantly lower than in healthy dogs.
    2 context sentences
    Summary · context
    In eight healthy dogs, the responses to ghrelin and GHRP-6 were compared to those of GH-releasing hormone (GHRH) and NaCl 0.9% (control).
    Summary · context
    In seven dogs with PDH, the effects of ghrelin and GHRP-6 were compared with their effects in healthy dogs.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In healthy dogs and in dogs with pituitary-dependent hyperadrenocorticism, GHRP‑6 did not cause a significant rise in plasma ACTH.

    In plain wordsIn healthy dogs and dogs with pituitary-dependent hyperadrenocorticism, GHRP‑6 did not raise ACTH in the blood.

    Peptide
    GHRP-6
    Outcome
    No significant changePlasma ACTH after GHRP-6
    Study

    dogn = 15

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ghrelin and GHRP-6 did not cause a significant rise in plasma ACTH and cortisol concentrations in either the healthy dogs or the dogs with PDH.
    2 context sentences
    Summary · context
    In eight healthy dogs, the responses to ghrelin and GHRP-6 were compared to those of GH-releasing hormone (GHRH) and NaCl 0.9% (control).
    Summary · context
    In seven dogs with PDH, the effects of ghrelin and GHRP-6 were compared with their effects in healthy dogs.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In healthy dogs and in dogs with pituitary-dependent hyperadrenocorticism, GHRP‑6 did not cause a significant rise in plasma cortisol.

    In plain wordsIn healthy dogs and dogs with pituitary-dependent hyperadrenocorticism, GHRP‑6 did not raise cortisol in the blood.

    Peptide
    GHRP-6
    Outcome
    No significant changePlasma cortisol after GHRP-6
    Study

    dogn = 15

    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Ghrelin and GHRP-6 did not cause a significant rise in plasma ACTH and cortisol concentrations in either the healthy dogs or the dogs with PDH.
    2 context sentences
    Summary · context
    In eight healthy dogs, the responses to ghrelin and GHRP-6 were compared to those of GH-releasing hormone (GHRH) and NaCl 0.9% (control).
    Summary · context
    In seven dogs with PDH, the effects of ghrelin and GHRP-6 were compared with their effects in healthy dogs.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In healthy dogs, GHRP‑6 caused a significant rise in plasma GH concentrations.

    In plain wordsIn healthy dogs, GHRP‑6 raised growth hormone levels in the blood.

    Peptide
    GHRP-6
    Outcome
    IncreasePlasma GH after GHRP-6 in healthy dogs
    Study

    dogn = 8

    Comparator
    NaCl 0.9% (control)
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the healthy dogs, GHRH, GHRP-6, and ghrelin caused a significant rise in plasma GH concentrations.
    2 context sentences
    Summary · context
    In eight healthy dogs, the responses to ghrelin and GHRP-6 were compared to those of GH-releasing hormone (GHRH) and NaCl 0.9% (control).
    Summary · context
    In seven dogs with PDH, the effects of ghrelin and GHRP-6 were compared with their effects in healthy dogs.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In healthy dogs, GHRP‑6 elicited significantly lower plasma GH concentrations than GHRH.

    In plain wordsIn healthy dogs, GHRP‑6 raised growth hormone less than GHRH did.

    Peptide
    GHRP-6
    Outcome
    DecreasePlasma GH after GHRP-6 versus GHRH in healthy dogs
    Study

    dogn = 8

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    GHRH administration elicited significantly higher plasma GH concentrations than administration of ghrelin and GHRP-6.
    2 context sentences
    Summary · context
    In eight healthy dogs, the responses to ghrelin and GHRP-6 were compared to those of GH-releasing hormone (GHRH) and NaCl 0.9% (control).
    Summary · context
    In seven dogs with PDH, the effects of ghrelin and GHRP-6 were compared with their effects in healthy dogs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.