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Study · Ex vivo tissue · mouse · 2002

5 results

Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway.

Khavinson VKh, Rybakina EG, Malinin VV, Pivanovich IY, Shanin SN, Korneva EA

Bulletin of experimental biology and medicine1 May 2002Cited by 4 (Europe PMC)

PMID12420072 (opens in a new tab)DOI10.1023/a:1019830308824 (opens in a new tab)PepBankPUB-12420072
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In mouse thymocytes, Epithalon had a comitogenic effect on proliferation that was less potent than that of Vilon.

    In plain wordsIn lab tests on mouse thymus cells, Epithalon promoted cell growth less strongly than Vilon did.

    Peptide
    Epitalon
    Outcome
    IncreaseComitogenic effect on thymocyte proliferation
    Study

    mousen: not reported in source

    Mouse thymocytes
    Comparator
    Vilon
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vilon produced the most potent comitogenic effect on thymocyte proliferation and modulated comitogenic activity of interleukin-1b. Epithalon was less potent, while Cortagen produced no such effects.
    1 context sentence
    Summary · context
    Immunomodulating effects of synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) and possible involvement of the sphingomyelin signal transduction pathway in their effects in mouse thymocytes were studied.
  2. 02LabEx vivo tissueMechanism

    In mouse thymocyte membranes, the stimulatory effect of Epithalon on sphingomyelinase activity was less pronounced than that of Vilon.

    In plain wordsIn lab tests on mouse thymus cell membranes, Epithalon affected sphingomyelinase activity less than Vilon did.

    Peptide
    Epitalon
    Outcome
    Direction not reportedSphingomyelinase activity in thymocyte membranes
    Study

    mousen: not reported in source

    Mouse thymocyte membranes
    Comparator
    Vilon
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vilon produced a more pronounced stimulatory effect on sphingomyelinase activity in mouse thymocyte membranes compared to Epithalon and Cortagen.
    1 context sentence
    Summary · context
    Immunomodulating effects of synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) and possible involvement of the sphingomyelin signal transduction pathway in their effects in mouse thymocytes were studied.
  3. 03LabIn vitro (cells)Mechanism

    In mouse thymocytes, Cortagen produced no comitogenic effect on proliferation.

    In plain wordsIn cells from mice, Cortagen did not stimulate thymocyte proliferation with a mitogen.

    Peptide
    Cortagen (AEDP)
    Outcome
    No significant changeComitogenic thymocyte proliferation
    Study

    mousen: not reported in source

    Mouse thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epithalon was less potent, while Cortagen produced no such effects.
    2 context sentences
    Summary · context
    Vilon produced the most potent comitogenic effect on thymocyte proliferation and modulated comitogenic activity of interleukin-1b.
    Summary · context
    Immunomodulating effects of synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) and possible involvement of the sphingomyelin signal transduction pathway in their effects in mouse thymocytes were studied.
  4. 04LabIn vitro (cells)Mechanism

    In mouse thymocytes, Cortagen did not modulate interleukin-1b comitogenic activity.

    In plain wordsIn cells from mice, Cortagen did not change interleukin-1b comitogenic activity.

    Peptide
    Cortagen (AEDP)
    Outcome
    No significant changeInterleukin-1b comitogenic activity
    Study

    mousen: not reported in source

    Mouse thymocytes
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Epithalon was less potent, while Cortagen produced no such effects.
    2 context sentences
    Summary · context
    Vilon produced the most potent comitogenic effect on thymocyte proliferation and modulated comitogenic activity of interleukin-1b.
    Summary · context
    Immunomodulating effects of synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) and possible involvement of the sphingomyelin signal transduction pathway in their effects in mouse thymocytes were studied.
  5. 05LabIn vitro (cell-free)Mechanism

    In mouse thymocyte membranes, Cortagen stimulated sphingomyelinase activity less than Vilon.

    In plain wordsIn lab tests with mouse thymocyte membranes, Cortagen stimulated sphingomyelinase activity less than Vilon.

    Peptide
    Cortagen (AEDP)
    Outcome
    DecreaseSphingomyelinase activity
    Study

    mousen: not reported in source

    Mouse thymocyte membranes
    Comparator
    Vilon
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Vilon produced a more pronounced stimulatory effect on sphingomyelinase activity in mouse thymocyte membranes compared to Epithalon and Cortagen.
    1 context sentence
    Summary · context
    Immunomodulating effects of synthetic peptides Vilon (Lys-Glu), Epithalon (Ala-Glu-Asp-Gly), and Cortagen (Ala-Glu-Asp-Pro) and possible involvement of the sphingomyelin signal transduction pathway in their effects in mouse thymocytes were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 10Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 7 times, first on 21 Oct 2026, 17:05 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 18:17 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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