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Study · Animal study (in vivo) · rat · 2002

11 results

Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).

Nakajima A, Shimoji N, Shiomi K, Shimizu S, Moriya H, Einhorn TA, Yamazaki M

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research1 Nov 2002Cited by 198 (Europe PMC)

PMID12412812 (opens in a new tab)DOI10.1359/jbmr.2002.17.11.2038 (opens in a new tab)PepBankPUB-12412812
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with femoral fractures, PTH increased callus bone mineral content at days 28 and 42 compared with vehicle.

    In plain wordsIn rats with fractures, PTH increased callus bone mineral content at days 28 and 42 compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus bone mineral content
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Measurements

    BMC increase
    61%
    Day 28 versus control
    BMC increase
    119%
    Day 42 versus control

    Source sentences

    Summary
    The results showed that on day 28 and day 42 after fracture, bone mineral content (BMC), bone mineral density (BMD), and ultimate load to failure of the calluses were significantly increased in the PTH-treated group compared with controls (day 28, 61, 46, and 32%; day 42, 119, 74, and 55%, respectively).
    2 context sentences
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with femoral fractures, PTH increased callus bone mineral density at days 28 and 42 compared with vehicle.

    In plain wordsIn rats with fractures, PTH increased callus bone density at days 28 and 42 compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus bone mineral density
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Measurements

    BMD increase
    46%
    Day 28 versus control
    BMD increase
    74%
    Day 42 versus control

    Source sentences

    Summary
    The results showed that on day 28 and day 42 after fracture, bone mineral content (BMC), bone mineral density (BMD), and ultimate load to failure of the calluses were significantly increased in the PTH-treated group compared with controls (day 28, 61, 46, and 32%; day 42, 119, 74, and 55%, respectively).
    2 context sentences
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with femoral fractures, PTH increased callus ultimate load to failure at days 28 and 42 compared with vehicle.

    In plain wordsIn rats with fractures, PTH increased callus breaking strength at days 28 and 42 compared with vehicle.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseCallus ultimate load to failure
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Measurements

    Ultimate load increase
    32%
    Day 28 versus control
    Ultimate load increase
    55%
    Day 42 versus control

    Source sentences

    Summary
    The results showed that on day 28 and day 42 after fracture, bone mineral content (BMC), bone mineral density (BMD), and ultimate load to failure of the calluses were significantly increased in the PTH-treated group compared with controls (day 28, 61, 46, and 32%; day 42, 119, 74, and 55%, respectively).
    2 context sentences
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, PTH increased PCNA-positive subperiosteal osteoprogenitor cells on day 2 compared with controls.

    In plain wordsIn rats with fractures, PTH increased PCNA-positive bone precursor cells on day 2 compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreasePCNA-positive osteoprogenitor cells
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The number of proliferating cell nuclear antigen (PCNA)-positive subperiosteal osteoprogenitor cells was significantly increased in the calluses of the PTH-treated group on day 2, and TRAP+ multinucleated cells were significantly increased in areas of callus cancellous bone on day 7.
    2 context sentences
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, PTH increased TRAP-positive multinucleated cells in callus cancellous bone on day 7 compared with controls.

    In plain wordsIn rats with fractures, PTH increased TRAP-positive multinucleated cells on day 7 compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseTRAP-positive multinucleated cells
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The number of proliferating cell nuclear antigen (PCNA)-positive subperiosteal osteoprogenitor cells was significantly increased in the calluses of the PTH-treated group on day 2, and TRAP+ multinucleated cells were significantly increased in areas of callus cancellous bone on day 7.
    2 context sentences
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, PTH increased type I collagen mRNA during early and later healing stages compared with controls.

    In plain wordsIn rats with fractures, PTH increased type I collagen mRNA during early and later healing compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseType I collagen mRNA
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The levels of expression of type I collagen (COLlA1), osteonectin (ON), ALP, and osteocalcin (OC) mRNA were increased markedly in the PTH-treated group and accompanied by enhanced expression of insulin-like growth factor (IGF)-I mRNA during the early stages of healing (days 4-7).
    3 context sentences
    Summary · context
    The increased expression of COL1A1, ON, ALP, and OC mRNA continued during the later stages of healing (days 14-21) despite a lack of up-regulation of IGF-I mRNA.
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, PTH increased osteonectin mRNA during early and later healing stages compared with controls.

    In plain wordsIn rats with fractures, PTH increased osteonectin mRNA during early and later healing compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseOsteonectin mRNA
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The levels of expression of type I collagen (COLlA1), osteonectin (ON), ALP, and osteocalcin (OC) mRNA were increased markedly in the PTH-treated group and accompanied by enhanced expression of insulin-like growth factor (IGF)-I mRNA during the early stages of healing (days 4-7).
    3 context sentences
    Summary · context
    The increased expression of COL1A1, ON, ALP, and OC mRNA continued during the later stages of healing (days 14-21) despite a lack of up-regulation of IGF-I mRNA.
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, PTH increased ALP mRNA during early and later healing stages compared with controls.

    In plain wordsIn rats with fractures, PTH increased ALP mRNA during early and later healing compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseALP mRNA
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The levels of expression of type I collagen (COLlA1), osteonectin (ON), ALP, and osteocalcin (OC) mRNA were increased markedly in the PTH-treated group and accompanied by enhanced expression of insulin-like growth factor (IGF)-I mRNA during the early stages of healing (days 4-7).
    3 context sentences
    Summary · context
    The increased expression of COL1A1, ON, ALP, and OC mRNA continued during the later stages of healing (days 14-21) despite a lack of up-regulation of IGF-I mRNA.
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, PTH increased osteocalcin mRNA during early and later healing stages compared with controls.

    In plain wordsIn rats with fractures, PTH increased osteocalcin mRNA during early and later healing compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseOsteocalcin mRNA
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The levels of expression of type I collagen (COLlA1), osteonectin (ON), ALP, and osteocalcin (OC) mRNA were increased markedly in the PTH-treated group and accompanied by enhanced expression of insulin-like growth factor (IGF)-I mRNA during the early stages of healing (days 4-7).
    3 context sentences
    Summary · context
    The increased expression of COL1A1, ON, ALP, and OC mRNA continued during the later stages of healing (days 14-21) despite a lack of up-regulation of IGF-I mRNA.
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, PTH enhanced IGF-I mRNA expression during early healing compared with controls.

    In plain wordsIn rats with fractures, PTH increased IGF-I mRNA during early healing compared with controls.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    IncreaseIGF-I mRNA during early healing
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The levels of expression of type I collagen (COLlA1), osteonectin (ON), ALP, and osteocalcin (OC) mRNA were increased markedly in the PTH-treated group and accompanied by enhanced expression of insulin-like growth factor (IGF)-I mRNA during the early stages of healing (days 4-7).
    2 context sentences
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats with fractures, PTH did not up-regulate IGF-I mRNA during later healing.

    In plain wordsIn rats with fractures, PTH did not increase IGF-I mRNA during later healing.

    Peptide
    Teriparatide (PTH 1-34)
    Outcome
    No significant changeIGF-I mRNA during later healing
    Study

    ratn: not reported in source

    Femoral fracture
    Comparator
    Vehicle
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    10 microg/kg daily · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The increased expression of COL1A1, ON, ALP, and OC mRNA continued during the later stages of healing (days 14-21) despite a lack of up-regulation of IGF-I mRNA.
    2 context sentences
    Summary · context
    Unilateral femoral fractures were produced and a daily subcutaneous injection of 10 microg/kg of PTH(1-34) was administered during the entire healing period. Control animals were injected with vehicle solution alone.
    Title · context
    Mechanisms for the enhancement of fracture healing in rats treated with intermittent low-dose human parathyroid hormone (1-34).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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