In rats ex copula, the oxytocin antagonist L-368899, given systemically or centrally, attenuated the pro-erectile effects of the melanocortin MC(4) agonist THIQ.
In plain wordsIn rats, a drug that blocks oxytocin receptors reduced the erection-promoting effect of another drug, THIQ.
- Peptide
- Oxytocin
- Outcome
- DecreaseAttenuation of THIQ-induced erectile activity by oxytocin antagonist L-368899
- Study
ratn: not reported in source
Rats ex copula- Outcome group
- Receptor activity and mechanism · Reproductive and sexual health
Source sentences
These pro-erectile effects were also attenuated by systemic or central administration of an oxytocin antagonist (L-368899, 1 mg/kg, i.v.).
1 context sentence(design, population, supporting numbers)
Systemic administration of a melanocortin MC(4) receptor agonist (N-[(3R)-1,2,3,4-tetrahydroisoquinolinium-3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)-2-[4-cyclohexyl-4-(1H-1,2,4-triazol-1ylmethyl)piperidin-1-yl]-2-oxoethylamine; THIQ) with high selectivity over other melanocortin receptors enhanced intra…
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.