Skip to content

Study · Measured the body's own peptide · 2002

4 results

The effect of exogenous melatonin on stimulated neurohypophysial hormone release in man.

Forsling ML, Williams AJ

Clinical endocrinology1 Nov 2002Cited by 9 (Europe PMC)

PMID12390335 (opens in a new tab)DOI10.1046/j.1365-2265.2002.01644.x (opens in a new tab)PepBankPUB-12390335
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelRandomized controlled trialMechanism

    In young men, plasma oxytocin showed a small but statistically significant increase after hypertonic saline administration.

    In plain wordsIn young men, the body's own oxytocin rose a little after a salt-solution infusion.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin after hypertonic saline infusion
    Study

    n = 24

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    there was a small but statistically significant (P < 0.05) increase in plasma oxytocin after hypertonic saline administration
    2 context sentences
    Summary · context
    This was a double-blind randomized crossover study with subjects being given oral doses of melatonin (0.5 mg or 5.0 mg) or placebo, before infusion of hypertonic saline or exercise.
    Summary · context
    Studies were performed on a total of 24 male subjects aged 19-23 years, who were entrained to a normal light-dark cycle and who refrained from taking heavy exercise, alcohol and smoking for 24 h prior to study.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelRandomized controlled trialMechanism

    In young men, exercise had no effect on plasma oxytocin release.

    In plain wordsIn young men, exercise did not change the body's own oxytocin level.

    Peptide
    Oxytocin
    Outcome
    No significant changePlasma oxytocin during exercise
    Study

    n = 24

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Although exercise had no effect on oxytocin release
    2 context sentences
    Summary · context
    This was a double-blind randomized crossover study with subjects being given oral doses of melatonin (0.5 mg or 5.0 mg) or placebo, before infusion of hypertonic saline or exercise.
    Summary · context
    Studies were performed on a total of 24 male subjects aged 19-23 years, who were entrained to a normal light-dark cycle and who refrained from taking heavy exercise, alcohol and smoking for 24 h prior to study.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelRandomized controlled trialMechanism

    In young men, 5.0 mg melatonin inhibited the rise in plasma oxytocin after hypertonic saline administration.

    In plain wordsIn young men, a high melatonin dose reduced the rise in the body's own oxytocin after a salt-solution infusion.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin response to hypertonic saline with 5.0 mg melatonin
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    which was inhibited by 5.0 mg and augmented by 0.5 mg melatonin.
    2 context sentences
    Summary · context
    This was a double-blind randomized crossover study with subjects being given oral doses of melatonin (0.5 mg or 5.0 mg) or placebo, before infusion of hypertonic saline or exercise.
    Summary · context
    Studies were performed on a total of 24 male subjects aged 19-23 years, who were entrained to a normal light-dark cycle and who refrained from taking heavy exercise, alcohol and smoking for 24 h prior to study.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelRandomized controlled trialMechanism

    In young men, 0.5 mg melatonin augmented the rise in plasma oxytocin after hypertonic saline administration.

    In plain wordsIn young men, a low melatonin dose increased the rise in the body's own oxytocin after a salt-solution infusion.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin response to hypertonic saline with 0.5 mg melatonin
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    which was inhibited by 5.0 mg and augmented by 0.5 mg melatonin.
    2 context sentences
    Summary · context
    This was a double-blind randomized crossover study with subjects being given oral doses of melatonin (0.5 mg or 5.0 mg) or placebo, before infusion of hypertonic saline or exercise.
    Summary · context
    Studies were performed on a total of 24 male subjects aged 19-23 years, who were entrained to a normal light-dark cycle and who refrained from taking heavy exercise, alcohol and smoking for 24 h prior to study.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.