Decrease of food intake by MC4-R agonist MTII in Siberian hamsters in long and short photoperiods.

Schuhler S, Horan TL, Hastings MH, Mercer JG, Morgan PJ, Ebling FJ

American journal of physiology. Regulatory, integrative and comparative physiology27 Sept 2002Cited by 18 (Europe PMC)

PMID12388479DOI10.1152/ajpregu.00331.2002PepBankPUB-12388479

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In male Siberian hamsters in long photoperiod, intracerebroventricular melanotan II significantly decreased food intake relative to vehicle over 6 hours.
In plain wordsIn hamsters, melanotan II injected into the brain reduced food intake over 6 hours compared with vehicle.
Peptide
Melanotan II
Outcome
DecreaseFood intake in long photoperiod
Study
Siberian hamstern: not reported in source
Male Siberian hamsters in long or short photoperiod
Comparator
Vehicle
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Siberian hamster).
Source sentences
Summary
In male hamsters maintained in long photoperiod (LP), intracerebroventricular injection of melanotan II (MTII) just before lights off significantly decreased food intake relative to vehicle treatment over the 6-h observation period.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of the hypothalamic melanocortin system in the regulation of food intake in the Siberian hamster, which shows a profound seasonal decrease in food intake and body weight in short photoperiod (SP).
Report a problemFND-1238847901
02AnimalAnimal study (in vivo)Efficacy outcome
In Siberian hamsters after 9 weeks of short daylength, melanotan II decreased food intake with effects similar to those in long photoperiod.
In plain wordsIn hamsters kept in short daylength, melanotan II reduced food intake as it did in long daylength.
Peptide
Melanotan II
Outcome
DecreaseFood intake in short photoperiod
Study
Siberian hamstern: not reported in source
Male Siberian hamsters in long or short photoperiod
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Siberian hamster).
Source sentences
Summary
Similar effects were observed in age-matched hamsters after exposure to a short daylength for 9 wk, when body weight had significantly decreased.
2 context sentences(design, population, supporting numbers)
Summary · context
In male hamsters maintained in long photoperiod (LP), intracerebroventricular injection of melanotan II (MTII) just before lights off significantly decreased food intake relative to vehicle treatment over the 6-h observation period.
Summary · context
We investigated the role of the hypothalamic melanocortin system in the regulation of food intake in the Siberian hamster, which shows a profound seasonal decrease in food intake and body weight in short photoperiod (SP).
Report a problemFND-1238847902
03AnimalAnimal study (in vivo)Efficacy outcome
In Siberian hamsters, there was no clear difference in the magnitude of response or the dose for half-maximal inhibition of food intake between short and long photoperiod.
In plain wordsIn hamsters, melanotan II worked about equally well on food intake in short and long daylength.
Peptide
Melanotan II
Outcome
No significant changeSensitivity to MTII in short versus long photoperiod
Study
Siberian hamstern: not reported in source
Male Siberian hamsters in long or short photoperiod
Comparator
Long photoperiod
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Siberian hamster).
Source sentences
Summary
There was no clear difference in either the magnitude of response or the dose required for half-maximal inhibition of food intake in hamsters in SP compared with those in LP.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of the hypothalamic melanocortin system in the regulation of food intake in the Siberian hamster, which shows a profound seasonal decrease in food intake and body weight in short photoperiod (SP).
Report a problemFND-1238847903
04AnimalAnimal study (in vivo)Other
In Siberian hamsters, melanotan II significantly increased grooming in both long and short photoperiod.
In plain wordsIn hamsters, melanotan II increased grooming in both long and short daylength.
Peptide
Melanotan II
Outcome
IncreaseGrooming
Study
Siberian hamstern: not reported in source
Male Siberian hamsters in long or short photoperiod
Outcome group
Anxiety and mood · Nervous system and cognition
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Siberian hamster).
Source sentences
Summary
MTII significantly increased grooming in both LP and SP.
1 context sentence(design, population, supporting numbers)
Summary · context
We investigated the role of the hypothalamic melanocortin system in the regulation of food intake in the Siberian hamster, which shows a profound seasonal decrease in food intake and body weight in short photoperiod (SP).
Report a problemFND-1238847904

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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