Skip to content

Study · Ex vivo tissue · mouse · 2002

5 results

Roles of insulin-like growth factors and their binding proteins in the differentiation of mouse tongue myoblasts.

Yamane A, Urushiyama T, Diekwisch TG

The International journal of developmental biology1 Sept 2002Cited by 14 (Europe PMC)

PMID12382947 (opens in a new tab)PepBankPUB-12382947
Publisher pageAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In mouse tongue organ cultures, low-concentration des(1‑3)IGF-I stimulated myoblast differentiation.

    In plain wordsIn lab tests, low-concentration des(1‑3)IGF-I stimulated muscle precursor cell differentiation in mouse tongue cultures.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseMyoblast differentiation at low concentration
    Study

    mousen: not reported in source

    tongue organ culture
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    low concentrationAs given in this study (mouse).

    Source sentences

    Summary
    A low concentration of des(1-3)IGF-I stimulated tongue myoblast differentiation, whereas high concentrations of des(1-3)IGF-I inhibited it.
    1 context sentence
    Summary · context
    To study the roles of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) in the differentiation of tongue myoblasts, we established a mouse tongue organ culture system and examined the effects of exogenous IGF-I, exogenous IGFBP4, 5, 6, and des(1-3)IGF-I, an IGF-I analogue with r…
  2. 02LabEx vivo tissueEfficacy outcome

    In mouse tongue organ cultures, high concentrations of des(1‑3)IGF-I inhibited myoblast differentiation.

    In plain wordsIn lab tests, high concentrations of des(1‑3)IGF-I inhibited muscle precursor cell differentiation in mouse tongue cultures.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseMyoblast differentiation at high concentrations
    Study

    mousen: not reported in source

    tongue organ culture
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    high concentrationsAs given in this study (mouse).

    Source sentences

    Summary
    A low concentration of des(1-3)IGF-I stimulated tongue myoblast differentiation, whereas high concentrations of des(1-3)IGF-I inhibited it.
    1 context sentence
    Summary · context
    To study the roles of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) in the differentiation of tongue myoblasts, we established a mouse tongue organ culture system and examined the effects of exogenous IGF-I, exogenous IGFBP4, 5, 6, and des(1-3)IGF-I, an IGF-I analogue with r…
  3. 03LabEx vivo tissueSafety outcome

    In mouse tongue organ cultures, high concentrations of des(1‑3)IGF-I were associated with abnormal tongue shape.

    In plain wordsIn lab tests, mouse tongues treated with high concentrations of des(1‑3)IGF-I had abnormal shapes.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    Not applicableAbnormal tongue shape
    Study

    mousen: not reported in source

    tongue organ culture
    Outcome group
    Adverse events · Musculoskeletal
    Studied dose
    high concentrationsAs given in this study (mouse).

    Source sentences

    Summary
    The abnormal shape of the tongue, low cell density and low staining intensity with hematoxylin and eosin in tongues treated with high concentrations of des(1-3)IGF-I, suggest that the inhibition is due to abnormal reactions of tongue tissues to the toxicity caused by high concentrations of des(1-3)IGF-I.
    1 context sentence
    Summary · context
    To study the roles of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) in the differentiation of tongue myoblasts, we established a mouse tongue organ culture system and examined the effects of exogenous IGF-I, exogenous IGFBP4, 5, 6, and des(1-3)IGF-I, an IGF-I analogue with r…
  4. 04LabEx vivo tissueSafety outcome

    In mouse tongue organ cultures, high concentrations of des(1‑3)IGF-I were associated with low cell density.

    In plain wordsIn lab tests, mouse tongues treated with high concentrations of des(1‑3)IGF-I had low cell density.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseLow cell density
    Study

    mousen: not reported in source

    tongue organ culture
    Outcome group
    Adverse events · Musculoskeletal
    Studied dose
    high concentrationsAs given in this study (mouse).

    Source sentences

    Summary
    The abnormal shape of the tongue, low cell density and low staining intensity with hematoxylin and eosin in tongues treated with high concentrations of des(1-3)IGF-I, suggest that the inhibition is due to abnormal reactions of tongue tissues to the toxicity caused by high concentrations of des(1-3)IGF-I.
    1 context sentence
    Summary · context
    To study the roles of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) in the differentiation of tongue myoblasts, we established a mouse tongue organ culture system and examined the effects of exogenous IGF-I, exogenous IGFBP4, 5, 6, and des(1-3)IGF-I, an IGF-I analogue with r…
  5. 05LabEx vivo tissueSafety outcome

    In mouse tongue organ cultures, high concentrations of des(1‑3)IGF-I were associated with low hematoxylin and eosin staining intensity.

    In plain wordsIn lab tests, mouse tongues treated with high concentrations of des(1‑3)IGF-I had low hematoxylin and eosin staining intensity.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseLow hematoxylin and eosin staining intensity
    Study

    mousen: not reported in source

    tongue organ culture
    Outcome group
    Adverse events · Musculoskeletal
    Studied dose
    high concentrationsAs given in this study (mouse).

    Source sentences

    Summary
    The abnormal shape of the tongue, low cell density and low staining intensity with hematoxylin and eosin in tongues treated with high concentrations of des(1-3)IGF-I, suggest that the inhibition is due to abnormal reactions of tongue tissues to the toxicity caused by high concentrations of des(1-3)IGF-I.
    1 context sentence
    Summary · context
    To study the roles of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) in the differentiation of tongue myoblasts, we established a mouse tongue organ culture system and examined the effects of exogenous IGF-I, exogenous IGFBP4, 5, 6, and des(1-3)IGF-I, an IGF-I analogue with r…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.