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Study · Animal study (in vivo) · dog · 2002

4 results

Effect of intrathecal and intravenous administration of oxytocin on amplitude of the reflex-evoked muscle action potential after electrical stimulation of the tooth pulp in anesthetized dogs.

Brown DC, Bernier N, Shofer F, Steinberg SA, Perkowski SZ

American journal of veterinary research1 Oct 2002Cited by 6 (Europe PMC)

PMID12371759 (opens in a new tab)DOI10.2460/ajvr.2002.63.1354 (opens in a new tab)PepBankPUB-12371759
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized dogs, intravenous oxytocin did not significantly change reflex-evoked muscle action potential amplitude compared with intravenous saline.

    In plain wordsIn dogs under anesthesia, oxytocin given into a vein did not change the pain-reflex response compared with saline.

    Peptide
    Oxytocin
    Outcome
    No significant changeREMP amplitude, IV oxytocin versus saline
    Study

    dogn = 6

    anesthetized male Beagles
    Comparator
    Saline (IV)
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intravenousAs given in this study (dog).

    Source sentences

    Summary
    There was not a significant change in REMP amplitude between saline solution and oxytocin administered IV.
    2 context sentences
    Summary · context
    6 male Beagles that were 2 to 6 years old.
    Summary · context
    Dogs were used in a crossover design with at least a 5-day washout period between treatments.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized dogs, reflex-evoked muscle action potential amplitude was higher with intravenous oxytocin than with intravenous morphine, which significantly inhibited it.

    In plain wordsIn dogs under anesthesia, the pain-reflex response was larger with oxytocin into a vein than with morphine, which reduced it.

    Peptide
    Oxytocin
    Outcome
    IncreaseREMP amplitude, IV oxytocin versus morphine
    Study

    dogn = 6

    anesthetized male Beagles
    Comparator
    Morphine (IV)
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intravenousAs given in this study (dog).

    Source sentences

    Summary
    Morphine administered IV significantly inhibited REMP amplitude, compared with IV administration of saline solution or oxytocin.
    2 context sentences
    Summary · context
    6 male Beagles that were 2 to 6 years old.
    Summary · context
    Dogs were used in a crossover design with at least a 5-day washout period between treatments.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized dogs, intrathecal oxytocin significantly increased reflex-evoked muscle action potential amplitude compared with intrathecal saline.

    In plain wordsIn dogs under anesthesia, oxytocin given into the spinal fluid increased the pain-reflex response compared with saline.

    Peptide
    Oxytocin
    Outcome
    IncreaseREMP amplitude, IT oxytocin versus saline
    Study

    dogn = 6

    anesthetized male Beagles
    Comparator
    Saline (IT)
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (dog).

    Source sentences

    Summary
    Intrathecal administration of oxytocin significantly increased REMP amplitude, compared with IT administration of saline solution or morphine.
    2 context sentences
    Summary · context
    6 male Beagles that were 2 to 6 years old.
    Summary · context
    Dogs were used in a crossover design with at least a 5-day washout period between treatments.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In anesthetized dogs, intrathecal oxytocin significantly increased reflex-evoked muscle action potential amplitude compared with intrathecal morphine.

    In plain wordsIn dogs under anesthesia, oxytocin given into the spinal fluid increased the pain-reflex response compared with morphine.

    Peptide
    Oxytocin
    Outcome
    IncreaseREMP amplitude, IT oxytocin versus morphine
    Study

    dogn = 6

    anesthetized male Beagles
    Comparator
    Morphine (IT)
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intrathecalAs given in this study (dog).

    Source sentences

    Summary
    Intrathecal administration of oxytocin significantly increased REMP amplitude, compared with IT administration of saline solution or morphine.
    2 context sentences
    Summary · context
    6 male Beagles that were 2 to 6 years old.
    Summary · context
    Dogs were used in a crossover design with at least a 5-day washout period between treatments.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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