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Study · Ex vivo tissue · helix pomatia · 2002

4 results

Selective suppression of the slow-inactivating potassium currents by nootropics in molluscan neurons.

Bukanova JV, Solntseva EI, Skrebitsky VG

The international journal of neuropsychopharmacology1 Sept 2002Cited by 12 (Europe PMC)

PMID12366875 (opens in a new tab)DOI10.1017/s1461145702002997 (opens in a new tab)PepBankPUB-12366875
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In isolated snail neurons, GVS-111 did not change the inward voltage-gated calcium current.

    In plain wordsIn lab tests of snail neurons, GVS-111 did not change the calcium current.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeVoltage-gated calcium current
    Study

    Helix pomatian: not reported in source

    isolated neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 nMAs given in this study (Helix pomatia).

    Source sentences

    Summary
    It has been found that I Ca was not changed in the presence of 30 microM vinpocetine, 100 microM piracetam or 10 nM GVS-111, while slow-inactivating, TEA-sensitive IK(Ca) and IKD were inhibited (IK(Ca) more strongly than IKD).
    1 context sentence
    Summary · context
    The experiments were performed on isolated neurons of the land snail Helix pomatia using a two-microelectrode voltage-clamp method.
  2. 02LabEx vivo tissueMechanism

    In isolated snail neurons, GVS-111 inhibited the slow-inactivating calcium-dependent potassium current more strongly than the delayed rectifying current.

    In plain wordsIn lab tests of snail neurons, GVS-111 inhibited the calcium-dependent potassium current more than the delayed rectifying current.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseCalcium-dependent potassium current
    Study

    Helix pomatian: not reported in source

    isolated neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 nMAs given in this study (Helix pomatia).

    Source sentences

    Summary
    It has been found that I Ca was not changed in the presence of 30 microM vinpocetine, 100 microM piracetam or 10 nM GVS-111, while slow-inactivating, TEA-sensitive IK(Ca) and IKD were inhibited (IK(Ca) more strongly than IKD).
    1 context sentence
    Summary · context
    The experiments were performed on isolated neurons of the land snail Helix pomatia using a two-microelectrode voltage-clamp method.
  3. 03LabEx vivo tissueMechanism

    In isolated snail neurons, GVS-111 inhibited the delayed rectifying potassium current.

    In plain wordsIn lab tests of snail neurons, GVS-111 reduced the delayed rectifying potassium current.

    Peptide
    Noopept (omberacetam)
    Outcome
    DecreaseDelayed rectifying potassium current
    Study

    Helix pomatian: not reported in source

    isolated neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 nMAs given in this study (Helix pomatia).

    Source sentences

    Summary
    It has been found that I Ca was not changed in the presence of 30 microM vinpocetine, 100 microM piracetam or 10 nM GVS-111, while slow-inactivating, TEA-sensitive IK(Ca) and IKD were inhibited (IK(Ca) more strongly than IKD).
    1 context sentence
    Summary · context
    The experiments were performed on isolated neurons of the land snail Helix pomatia using a two-microelectrode voltage-clamp method.
  4. 04LabEx vivo tissueMechanism

    In isolated snail neurons, low GVS-111 concentrations did not diminish the fast-inactivating potassium current.

    In plain wordsIn lab tests of snail neurons, low GVS-111 concentrations did not reduce the fast-inactivating potassium current.

    Peptide
    Noopept (omberacetam)
    Outcome
    No significant changeFast-inactivating potassium current
    Study

    Helix pomatian: not reported in source

    isolated neurons
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10 nMAs given in this study (Helix pomatia).

    Source sentences

    Summary
    In contrast, the fast-inactivating, 4-AP-sensitive K+ current (IA) was not diminished by low concentrations of piracetam and GVS-111, while vinpocetine even augmented it.
    2 context sentences
    Summary · context
    It has been found that I Ca was not changed in the presence of 30 microM vinpocetine, 100 microM piracetam or 10 nM GVS-111, while slow-inactivating, TEA-sensitive IK(Ca) and IKD were inhibited (IK(Ca) more strongly than IKD).
    Summary · context
    The experiments were performed on isolated neurons of the land snail Helix pomatia using a two-microelectrode voltage-clamp method.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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