Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology.

Anisimov SV, Bokheler KR, Khavinson VKh, Anisimov VN

Bulletin of experimental biology and medicine1 Mar 2002Cited by 14 (Europe PMC)

PMID12360356DOI10.1023/a:1015859322630PepBankPUB-12360356

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In mouse heart, Epithalon changed the expression of 98 clones by more than 2-fold.
In plain wordsIn mice, Epithalon changed the activity of 98 genes in the heart.
Peptide
Epitalon
Outcome
MixedNumber of heart gene clones changed by Epithalon
Study
mousen: not reported in source
Mouse heart, cDNA clone microarray
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Measurements
Clones with changed expression
98 clones
Epithalon
Source sentences
Summary
Vilon changed expression of 36 clones, while Epithalon modulated expression of 98 clones.
2 context sentences(design, population, supporting numbers)
Summary · context
We revealed 300 clones (1.94% of the total count), whose expression changed more than by 2 times.
Summary · context
Expression of 15,247 clones from a cDNA library in the heart of mice receiving Vilon and Epithalon was studied by DNA-microarray technology.
Report a problemFND-1236035601

Studies that did not test the peptide alone3

In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Epitalon.

02AnimalNot a test of Epitalon aloneAnimal study (in vivo)Mechanism
In mouse heart, Epithalon alone or with Vilon activated 194 clones, at most by 6.61 times.
In plain wordsIn mice, Epithalon, alone or with Vilon, raised the activity of 194 heart genes.
Peptide
Epitalon
Outcome
IncreaseHeart gene clones activated by Epithalon
Study
mousen: not reported in source
Mouse heart, cDNA clone microarray
Outcome group
Receptor activity and mechanism · Cardiovascular
Measurements
Clones activated
194 clones
Epithalon alone or with Vilon
Maximum activation
6.61 times
Epithalon alone or with Vilon
Source sentences
Summary
Epithalon alone or in combination with Vilon activated expression of 194 clones (maximally by 6.61 times)
1 context sentence(design, population, supporting numbers)
Summary · context
Expression of 15,247 clones from a cDNA library in the heart of mice receiving Vilon and Epithalon was studied by DNA-microarray technology.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-1236035602
03AnimalNot a test of Epitalon aloneAnimal study (in vivo)Mechanism
In mouse heart, Epithalon alone or with Vilon inhibited 48 clones, at most by 2.71 times.
In plain wordsIn mice, Epithalon, alone or with Vilon, lowered the activity of 48 heart genes.
Peptide
Epitalon
Outcome
DecreaseHeart gene clones inhibited by Epithalon
Study
mousen: not reported in source
Mouse heart, cDNA clone microarray
Outcome group
Receptor activity and mechanism · Cardiovascular
Measurements
Clones inhibited
48 clones
Epithalon alone or with Vilon
Maximum inhibition
2.71 times
Epithalon alone or with Vilon
Source sentences
Summary
and inhibited expression of 48 clones (maximally by 2.71 times).
1 context sentence(design, population, supporting numbers)
Summary · context
Expression of 15,247 clones from a cDNA library in the heart of mice receiving Vilon and Epithalon was studied by DNA-microarray technology.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-1236035603
04AnimalNot a test of Epitalon aloneAnimal study (in vivo)Mechanism
In mouse heart, combined treatment with Vilon and Epithalon changed the expression of 144 clones.
In plain wordsIn mice, Epithalon combined with Vilon changed the activity of 144 heart genes.
Peptide
Epitalon
Outcome
MixedHeart gene clones changed by combined Vilon and Epithalon
Study
mousen: not reported in source
Mouse heart, cDNA clone microarray
Outcome group
Receptor activity and mechanism · Cardiovascular
Measurements
Clones with changed expression
144 clones
Vilon plus Epithalon
Source sentences
Summary
Combined treatment with Vilon and Epithalon changed expression of 144 clones.
1 context sentence(design, population, supporting numbers)
Summary · context
Expression of 15,247 clones from a cDNA library in the heart of mice receiving Vilon and Epithalon was studied by DNA-microarray technology.
In this study, Epitalon was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Epitalon.
Report a problemFND-1236035604

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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