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Study · Animal study (in vivo) · rat · 2002

3 results

Effects of epithalon on activities gastrointestinal enzymes in young and old rats.

Khavinson VKh, Malinin VV, Timofeeva NM, Egorova VV, Nikitina AA

Bulletin of experimental biology and medicine1 Mar 2002Cited by 4 (Europe PMC)

PMID12360355 (opens in a new tab)DOI10.1023/a:1015807305791 (opens in a new tab)PepBankPUB-12360355
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, peroral Epithalon changed the activity of enzymes hydrolyzing carbohydrates, proteins and phosphoric acid esters in the gastrointestinal tract.

    In plain wordsIn rats, Epithalon by mouth changed the activity of digestive enzymes in the gut.

    Peptide
    Epitalon
    Outcome
    MixedActivity of gastrointestinal enzymes
    Study

    ratn: not reported in source

    Male and female Wistar rats aged 3 and 11 months
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    Dose not stated · oralAs given in this study (rat).

    Source sentences

    Summary
    changed activity of enzymes hydrolyzing carbohydrates, proteins, and phosphoric acid esters in various portions of the gastrointestinal tract.
    1 context sentence
    Summary · context
    Peroral administration of Epithalon (Ala-Glu-Asp-Gly) to male and female Wistar rats aging 3 and 11 months changed activity of enzymes hydrolyzing carbohydrates, proteins, and phosphoric acid esters in various portions of the gastrointestinal tract.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, the most pronounced activation of gastrointestinal enzymes occurred in 11-month-old animals.

    In plain wordsIn rats, Epithalon raised digestive enzyme activity most in the 11-month-old animals.

    Peptide
    Epitalon
    Outcome
    IncreaseEnzyme activation in 11-month-old rats
    Study

    ratn: not reported in source

    Male and female Wistar rats aged 3 and 11 months
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    Dose not stated · oralAs given in this study (rat).

    Source sentences

    Summary
    The most pronounced activation of enzymes was observed in 11-month-old animals.
    1 context sentence
    Summary · context
    Peroral administration of Epithalon (Ala-Glu-Asp-Gly) to male and female Wistar rats aging 3 and 11 months changed activity of enzymes hydrolyzing carbohydrates, proteins, and phosphoric acid esters in various portions of the gastrointestinal tract.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats, Epithalon diminished the differences in gastrointestinal enzyme activities between young and old rats compared with untreated animals.

    In plain wordsIn rats, Epithalon narrowed the gap in digestive enzyme activity between young and old animals compared with untreated animals.

    Peptide
    Epitalon
    Outcome
    DecreaseDifference in enzyme activity between young and old rats
    Study

    ratn: not reported in source

    Male and female Wistar rats aged 3 and 11 months
    Comparator
    Untreated animals
    Outcome group
    Gastrointestinal function · Gastrointestinal
    Studied dose
    Dose not stated · oralAs given in this study (rat).

    Source sentences

    Summary
    This effect diminished the differences in enzyme activities between young and old rats (compared to untreated animals).
    1 context sentence
    Summary · context
    Peroral administration of Epithalon (Ala-Glu-Asp-Gly) to male and female Wistar rats aging 3 and 11 months changed activity of enzymes hydrolyzing carbohydrates, proteins, and phosphoric acid esters in various portions of the gastrointestinal tract.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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