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Study · In vitro (cells) · mouse · 2002

3 results

Inhibition of insulin-like growth factor I activity contributes to the premature apoptosis of cerebellar granule neuron in weaver mutant mice: in vitro analysis.

Zhong J, Deng J, Ghetti B, Lee WH

Journal of neuroscience research1 Oct 2002Cited by 17 (Europe PMC)

PMID12237862 (opens in a new tab)DOI10.1002/jnr.10360 (opens in a new tab)PepBankPUB-12237862
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In weaver mutant mouse granule neurons, des(1‑3)IGF-I promoted survival more effectively than IGF-I at the same concentration.

    In plain wordsIn cells from weaver mutant mice, des(1‑3)IGF-I improved neuron survival more than IGF-I at the same concentration.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseNeuron survival
    Study

    mousen: not reported in source

    weaver mutant cerebellar granule neurons
    Comparator
    IGF-I at the same concentration
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the same concentration, des(1-3) IGF-I was more effective than IGF-I in promoting survival, in increasing Akt activity, and in decreasing caspase 3 activity.
    2 context sentences
    Summary · context
    To understand IGF-I's function during cerebellar development, we examined the involvement of IGF-I in the premature apoptosis of granule neurons derived from the cerebella of weaver (wv) mutant mice.
    Summary · context
    To delineate the interaction between IGF-I and IGFBP5 on wv granule neurons, we examined neuronal survival after treating with IGF-I, des(1-3) IGF-I, or IGFBP5 antibody.
  2. 02LabIn vitro (cells)Mechanism

    In weaver mutant mouse granule neurons, des(1‑3)IGF-I increased Akt activity more effectively than IGF-I at the same concentration.

    In plain wordsIn cells from weaver mutant mice, des(1‑3)IGF-I increased Akt activity more than IGF-I at the same concentration.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseAkt activity
    Study

    mousen: not reported in source

    weaver mutant cerebellar granule neurons
    Comparator
    IGF-I at the same concentration
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the same concentration, des(1-3) IGF-I was more effective than IGF-I in promoting survival, in increasing Akt activity, and in decreasing caspase 3 activity.
    2 context sentences
    Summary · context
    To understand IGF-I's function during cerebellar development, we examined the involvement of IGF-I in the premature apoptosis of granule neurons derived from the cerebella of weaver (wv) mutant mice.
    Summary · context
    To delineate the interaction between IGF-I and IGFBP5 on wv granule neurons, we examined neuronal survival after treating with IGF-I, des(1-3) IGF-I, or IGFBP5 antibody.
  3. 03LabIn vitro (cells)Mechanism

    In weaver mutant mouse granule neurons, des(1‑3)IGF-I decreased caspase 3 activity more effectively than IGF-I at the same concentration.

    In plain wordsIn cells from weaver mutant mice, des(1‑3)IGF-I decreased caspase 3 activity more than IGF-I at the same concentration.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseCaspase 3 activity
    Study

    mousen: not reported in source

    weaver mutant cerebellar granule neurons
    Comparator
    IGF-I at the same concentration
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    At the same concentration, des(1-3) IGF-I was more effective than IGF-I in promoting survival, in increasing Akt activity, and in decreasing caspase 3 activity.
    2 context sentences
    Summary · context
    To understand IGF-I's function during cerebellar development, we examined the involvement of IGF-I in the premature apoptosis of granule neurons derived from the cerebella of weaver (wv) mutant mice.
    Summary · context
    To delineate the interaction between IGF-I and IGFBP5 on wv granule neurons, we examined neuronal survival after treating with IGF-I, des(1-3) IGF-I, or IGFBP5 antibody.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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