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Study · In vitro (cells) · 2002

6 results

Peptide antagonists of ethanol inhibition of l1-mediated cell-cell adhesion.

Wilkemeyer MF, Menkari CE, Spong CY, Charness ME

The Journal of pharmacology and experimental therapeutics1 Oct 2002Cited by 37 (Europe PMC)

PMID12235240 (opens in a new tab)DOI10.1124/jpet.102.036277 (opens in a new tab)PepBankPUB-12235240
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human L1-transfected NIH/3T3 cells, NAP did not alter L1 adhesion.

    In plain wordsIn cells, NAP did not change L1-mediated adhesion.

    Peptide
    Davunetide
    Outcome
    No significant changeL1-mediated adhesion without ethanol
    Study

    n: not reported in source

    Human L1-transfected NIH/3T3 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither NAP nor SAL altered L1 adhesion or L1 expression;
    1 context sentence
    Summary · context
    Aggregation assays were carried out in ethanol-sensitive, human L1-transfected NIH/3T3 cells in the absence and presence of NAP and SAL.
  2. 02LabIn vitro (cells)Mechanism

    In human L1-transfected NIH/3T3 cells, NAP did not alter L1 expression.

    In plain wordsIn cells, NAP did not change L1 expression.

    Peptide
    Davunetide
    Outcome
    No significant changeL1 expression
    Study

    n: not reported in source

    Human L1-transfected NIH/3T3 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Neither NAP nor SAL altered L1 adhesion or L1 expression;
    1 context sentence
    Summary · context
    Aggregation assays were carried out in ethanol-sensitive, human L1-transfected NIH/3T3 cells in the absence and presence of NAP and SAL.
  3. 03LabIn vitro (cells)Mechanism

    In human L1-transfected NIH/3T3 cells, NAP completely antagonized ethanol inhibition of L1 adhesion, with EC(50) of 6 x 10(-14) M.

    In plain wordsIn cells, NAP completely blocked ethanol inhibition of L1 adhesion compared with ethanol alone.

    Peptide
    Davunetide
    Outcome
    DecreaseEthanol inhibition of L1 adhesion
    Study

    n: not reported in source

    Human L1-transfected NIH/3T3 cells
    Comparator
    Ethanol alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    EC(50)
    6 x 10(-14) M
    NAP antagonism of ethanol inhibition

    Source sentences

    Summary
    Neither NAP nor SAL altered L1 adhesion or L1 expression; however, both peptides potently and completely antagonized the inhibition of L1 adhesion by 100 mM ethanol (EC(50): NAP, 6 x 10(-14) M; SAL, 4 x 10(-11) M).
    1 context sentence
    Summary · context
    Aggregation assays were carried out in ethanol-sensitive, human L1-transfected NIH/3T3 cells in the absence and presence of NAP and SAL.
  4. 04LabIn vitro (cells)Mechanism

    In bone morphogenetic protein-7-treated NG108-15 cells, NAP antagonized ethanol inhibition of cell-cell adhesion.

    In plain wordsIn cells, NAP blocked ethanol inhibition of cell adhesion compared with ethanol alone.

    Peptide
    Davunetide
    Outcome
    DecreaseEthanol inhibition of cell-cell adhesion in NG108-15 cells
    Study

    n: not reported in source

    Bone morphogenetic protein-7-treated NG108-15 cells
    Comparator
    Ethanol alone
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NAP also antagonized ethanol inhibition of cell-cell adhesion in bone morphogenetic protein-7-treated NG108-15 cells.
    1 context sentence
    Summary · context
    Aggregation assays were carried out in ethanol-sensitive, human L1-transfected NIH/3T3 cells in the absence and presence of NAP and SAL.
  5. 05LabIn vitro (cells)Mechanism

    In L1-expressing NIH/3T3 cells, NAP antagonism was irreversible.

    In plain wordsIn cells, NAP's blocking effect was irreversible.

    Peptide
    Davunetide
    Outcome
    Not applicableReversibility of ethanol antagonism
    Study

    n: not reported in source

    Human L1-transfected NIH/3T3 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, NAP antagonism was irreversible and could not be overcome by increasing agonist concentration.
    1 context sentence
    Summary · context
    Aggregation assays were carried out in ethanol-sensitive, human L1-transfected NIH/3T3 cells in the absence and presence of NAP and SAL.
  6. 06LabIn vitro (cells)Mechanism

    In L1-expressing NIH/3T3 cells, increasing agonist concentration could not overcome NAP antagonism.

    In plain wordsIn cells, increasing agonist concentration did not overcome NAP's blocking effect.

    Peptide
    Davunetide
    Outcome
    No significant changeAntagonism with increasing agonist concentration
    Study

    n: not reported in source

    Human L1-transfected NIH/3T3 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In contrast, NAP antagonism was irreversible and could not be overcome by increasing agonist concentration.
    1 context sentence
    Summary · context
    Aggregation assays were carried out in ethanol-sensitive, human L1-transfected NIH/3T3 cells in the absence and presence of NAP and SAL.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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