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Study · Animal study (in vivo) · mouse · 2002

2 results

Insulin-like growth factor binding protein-5 (IGFBP-5) induces premature cell death in the mammary glands of transgenic mice.

Tonner E, Barber MC, Allan GJ, Beattie J, Webster J, Whitelaw CB, Flint DJ

Development (Cambridge, England)1 Oct 2002Cited by 86 (Europe PMC)

PMID12223411 (opens in a new tab)DOI10.1242/dev.129.19.4547 (opens in a new tab)PepBankPUB-12223411
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In transgenic mice that overexpress IGFBP-5 in the mammary gland, R3-IGF-I delivered by minipump normalised mammary gland weight and DNA content.

    In plain wordsIn mice with impaired mammary development, an IGF-1 analogue brought mammary gland weight and DNA content back to normal.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseMammary gland weight and DNA content
    Study

    mousen: not reported in source

    transgenic mice expressing IGFBP-5 in the mammary gland
    Outcome group
    Lactation and milk synthesis · Reproductive and sexual health
    Studied dose
    Dose not stated · minipumpAs given in this study (mouse).

    Source sentences

    Summary
    In contrast mammary development (gland weight and DNA content) was normalised by R3-IGF-I
    2 context sentences
    Summary · context
    To demonstrate a causal relationship between IGFBP-5 and cell death we created transgenic mice expressing IGFBP-5 in the mammary gland using a mammary-specific promoter, beta-lactoglobulin.
    Summary · context
    We attempted to "rescue" the transgenic phenotype by using growth hormone to increase endogenous IGF-I concentrations or by implanting minipumps delivering an IGF-1 analogue, R(3)-IGF-1, which binds weakly to IGFBP-5.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In transgenic mice that overexpress IGFBP-5 in the mammary gland, R3-IGF-I only partially restored milk production.

    In plain wordsIn mice with impaired mammary development, an IGF-1 analogue only partly restored milk production.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseMilk production
    Study

    mousen: not reported in source

    transgenic mice expressing IGFBP-5 in the mammary gland
    Outcome group
    Lactation and milk synthesis · Reproductive and sexual health
    Studied dose
    Dose not stated · minipumpAs given in this study (mouse).

    Source sentences

    Summary
    although milk production was only partially restored.
    2 context sentences
    Summary · context
    To demonstrate a causal relationship between IGFBP-5 and cell death we created transgenic mice expressing IGFBP-5 in the mammary gland using a mammary-specific promoter, beta-lactoglobulin.
    Summary · context
    We attempted to "rescue" the transgenic phenotype by using growth hormone to increase endogenous IGF-I concentrations or by implanting minipumps delivering an IGF-1 analogue, R(3)-IGF-1, which binds weakly to IGFBP-5.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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