In mouse embryos and deciduas, VIP levels were higher after peptide pretreatment and alcohol than after alcohol alone at 12 and 24 h.
In plain wordsIn mice, the peptide combination preserved embryo/decidual VIP levels compared with alcohol alone at 12 and 24 h.
- Peptide
- Davunetide
- Outcome
- IncreaseEmbryo/decidual VIP levels
- Study
mousen: not reported in source
Fetal alcohol syndrome- Comparator
- Alcohol alone
- Outcome group
- Neuroprotection · Nervous system and cognition
Source sentences
However, in the embryo/deciduas at 12 and 24 h, VIP levels were below the EIA's detection limit in the alcohol-treated groups, and significantly lower than the control or peptide-pretreated groups (p<0.05).
2 context sentences(design, population, supporting numbers)
Previous work has demonstrated that peptide agonists (SALLRSIPA and NAPVSIPQ) from downstream mediators that are regulated by VIP were able to prevent the alcohol-induced fetal death, growth restriction and microcephaly associated with fetal alcohol syndrome.
Here we evaluated the role of VIP in this mouse model of fetal alcohol syndrome, to determine if fetal or maternal levels of VIP are altered. In addition, we evaluated whether peptide treatment would alter the effects of alcohol on VIP levels. Treatment groups included control, alcohol, and alcohol+peptides.
In this study, Davunetide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Davunetide.