Skip to content

Study · Animal study (in vivo) · rat · 2002

2 results

Estradiol treatment fails to affect the feeding responses to melanocortin-3/4 receptor agonism or antagonism in ovariectomized rats.

Polidori C, Geary N

Peptides1 Sept 2002Cited by 19 (Europe PMC)

PMID12217431 (opens in a new tab)DOI10.1016/s0196-9781(02)00112-2 (opens in a new tab)PepBankPUB-12217431
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In ovariectomized rats, lateral ventricular injection of the MC3/4 agonist MTII at 0.5 nmol decreased feeding.

    In plain wordsIn female rats without ovaries, MTII given into the brain reduced feeding.

    Peptide
    Melanotan II
    Outcome
    DecreaseFeeding
    Study

    ratn: not reported in source

    Ovariectomized Long-Evans rats with estradiol replacement
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    0.5 nmol · lateral ventricular injectionAs given in this study (rat).

    Source sentences

    Summary
    LICV injections of 0.5 nmol of the MC3/4 agonist MTII decreased feeding
    1 context sentence
    Summary · context
    Ovariectomized Long-Evans rats with lateral ventricular (LICV) injection cannulae were maintained on a near-physiological, cyclic schedule of E2 treatment.

Studies that did not test the peptide alone1

In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Melanotan II.

  1. 02AnimalNot a test of Melanotan II aloneAnimal study (in vivo)Mechanism

    In ovariectomized rats, estradiol treatment did not affect the feeding response to MTII (MTII was the challenge).

    In plain wordsIn female rats without ovaries, estradiol did not change how MTII reduced feeding.

    Peptide
    Melanotan II
    Outcome
    No significant changeEffect of estradiol treatment on the feeding response to MTII
    Study

    ratn: not reported in source

    Ovariectomized Long-Evans rats with estradiol replacement
    Outcome group
    Appetite and food intake · Metabolic and weight

    Source sentences

    Summary
    None of these effects was affected by E2 treatment.
    1 context sentence
    Summary · context
    Ovariectomized Long-Evans rats with lateral ventricular (LICV) injection cannulae were maintained on a near-physiological, cyclic schedule of E2 treatment.

    In this study, Melanotan II was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan II.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.