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Study · Not a test of the peptide alone · 2002

4 results

A single growth hormone (GH) determination is sufficient for the diagnosis of GH-deficiency in adult patients using the growth hormone releasing hormone plus growth hormone releasing peptide-6 test.

Leal A, Lage M, Popovic V, Torres E, Koppeschaar HP, Paramo C, Micic D, Garcia-Mayor RV, Dieguez C, Casanueva FF

Clinical endocrinology1 Sept 2002Cited by 13 (Europe PMC)

PMID12201831 (opens in a new tab)DOI10.1046/j.1365-2265.2002.01623.x (opens in a new tab)PepBankPUB-12201831
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 01HumanNot a test of GHRP-6 aloneObservational studyActivity measurement

    In adults, GHRH plus GHRP‑6-evoked GH peaks did not correlate with basal GH in controls or patients.

    In plain wordsIn adults, GH peaks after the combined test were not linked to basal GH levels.

    Peptide
    GHRP-6
    Outcome
    No significant changeGH peak and basal GH correlation
    Study

    n = 349

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    GHRH + GHRP-6-evoked GH peaks in controls and patients were not correlated with GH basal values, making this determination useless for test validation.
    2 context sentences
    Summary · context
    Three hundred and forty-nine adult subjects (146 patients with organic pituitary disease and 203 healthy subjects) were studied.
    Summary · context
    All were administered GHRH 1 micro g/kg i.v. plus GHRP-6 1 micro g/kg i.v. at 0 minutes, and blood samples were obtained at regular intervals.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 02HumanNot a test of GHRP-6 aloneObservational studyActivity measurement

    In adults, GH at 30 minutes after GHRH plus GHRP‑6 correlated strongly with peak GH.

    In plain wordsIn adults, GH at 30 minutes after the combined test correlated strongly with peak GH.

    Peptide
    GHRP-6
    Outcome
    Not applicableGH at 30 minutes and peak correlation
    Study

    n = 349

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Correlation
    0.994 r
    30-minute GH versus peak

    Source sentences

    Summary
    In contrast, an excellent correlation was observed between GH values at 30 minutes and the GH peaks (r = 0.994, P < 0.0001).
    2 context sentences
    Summary · context
    Three hundred and forty-nine adult subjects (146 patients with organic pituitary disease and 203 healthy subjects) were studied.
    Summary · context
    All were administered GHRH 1 micro g/kg i.v. plus GHRP-6 1 micro g/kg i.v. at 0 minutes, and blood samples were obtained at regular intervals.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  3. 03HumanNot a test of GHRP-6 aloneObservational studyActivity measurement

    Using 30-minute GH instead of peak GH after GHRH plus GHRP‑6 reclassified five controls from normal to uncertain.

    In plain wordsUsing the combined test's 30-minute GH instead of peak GH changed five controls from normal to uncertain.

    Peptide
    GHRP-6
    Outcome
    Not applicableControl diagnostic reclassification
    Study

    n = 203

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Controls reclassified from normal to uncertain
    5 subjects
    30-minute GH used instead of peak GH, out of 203 control subjects

    Source sentences

    Summary
    When comparing the 30-minute GH values against the peaks, the biochemical classification changed from normal toward uncertain in only five out of 203 control subjects, which is without clinical relevance according to Bayes theorem.
    2 context sentences
    Summary · context
    Three hundred and forty-nine adult subjects (146 patients with organic pituitary disease and 203 healthy subjects) were studied.
    Summary · context
    All were administered GHRH 1 micro g/kg i.v. plus GHRP-6 1 micro g/kg i.v. at 0 minutes, and blood samples were obtained at regular intervals.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  4. 04HumanNot a test of GHRP-6 aloneObservational studyActivity measurement

    Using 30-minute GH instead of peak GH after GHRH plus GHRP‑6 reclassified two patients from uncertain to GH deficient.

    In plain wordsUsing the combined test's 30-minute GH instead of peak GH changed two patients from uncertain to GH deficient.

    Peptide
    GHRP-6
    Outcome
    Not applicablePatient diagnostic reclassification
    Study

    n = 146

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Patients moved from uncertain to GH deficient
    2 patients
    30-minute GH used instead of peak GH, out of 146 GH deficient patients

    Source sentences

    Summary
    Similarly, when the 30-minute value was used instead of the peak in GH deficient patients, only two out of 146 patients moved from the uncertain area toward the GH deficient one.
    2 context sentences
    Summary · context
    Three hundred and forty-nine adult subjects (146 patients with organic pituitary disease and 203 healthy subjects) were studied.
    Summary · context
    All were administered GHRH 1 micro g/kg i.v. plus GHRP-6 1 micro g/kg i.v. at 0 minutes, and blood samples were obtained at regular intervals.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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