Increased density of glutamate receptor subunit 1 due to Cerebrolysin treatment: an immunohistochemical study on aged rats.

Eder P, Reinprecht I, Schreiner E, Skofitsch G, Windisch M

The Histochemical journal1 Nov 2001Cited by 14 (Europe PMC)

PMID12197668DOI10.1023/a:1016394031947PepBankPUB-12197668

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In aged rats, Cerebrolysin significantly increased GluR1 density in most measured hippocampal regions versus saline.
In plain wordsIn rats, Cerebrolysin increased hippocampal GluR1 receptor density compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseHippocampal GluR1 density
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Cerebrolysin and E021 increased GluR1 density in most measured regions of the hippocampal formation in a highly significant way.
1 context sentence(design, population, supporting numbers)
Summary · context
In order to examine the effect of the drug on the density of GluR1 in hippocampal formation 24-month-old rats were treated with either Cerebrolysin or its peptide fraction E021, or saline as a control.
Report a problemFND-1219766801
02AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, Cerebrolysin improved learning compared with saline.
In plain wordsIn rats, Cerebrolysin improved learning compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseLearning
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
These results correlate with the behavioural outcome, revealing an improvement in learning and memory of these rats after treatment with Cerebrolysin and E021.
1 context sentence(design, population, supporting numbers)
Summary · context
In order to examine the effect of the drug on the density of GluR1 in hippocampal formation 24-month-old rats were treated with either Cerebrolysin or its peptide fraction E021, or saline as a control.
Report a problemFND-1219766803
03AnimalAnimal study (in vivo)Efficacy outcome
In aged rats, Cerebrolysin improved memory compared with saline.
In plain wordsIn rats, Cerebrolysin improved memory compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseMemory
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
These results correlate with the behavioural outcome, revealing an improvement in learning and memory of these rats after treatment with Cerebrolysin and E021.
1 context sentence(design, population, supporting numbers)
Summary · context
In order to examine the effect of the drug on the density of GluR1 in hippocampal formation 24-month-old rats were treated with either Cerebrolysin or its peptide fraction E021, or saline as a control.
Report a problemFND-1219766804

Studies that did not test the peptide alone3

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

04AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Mechanism
In aged rats, the Cerebrolysin peptide fraction E021 significantly increased GluR1 density in most measured hippocampal regions versus saline.
In plain wordsIn rats, the Cerebrolysin fraction E021 increased hippocampal GluR1 receptor density compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseHippocampal GluR1 density with E021 fraction
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Cerebrolysin and E021 increased GluR1 density in most measured regions of the hippocampal formation in a highly significant way.
1 context sentence(design, population, supporting numbers)
Summary · context
In order to examine the effect of the drug on the density of GluR1 in hippocampal formation 24-month-old rats were treated with either Cerebrolysin or its peptide fraction E021, or saline as a control.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1219766802
05AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In aged rats, the Cerebrolysin peptide fraction E021 improved learning compared with saline.
In plain wordsIn rats, the Cerebrolysin peptide fraction E021 improved learning compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseLearning with E021 fraction
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
These results correlate with the behavioural outcome, revealing an improvement in learning and memory of these rats after treatment with Cerebrolysin and E021.
1 context sentence(design, population, supporting numbers)
Summary · context
In order to examine the effect of the drug on the density of GluR1 in hippocampal formation 24-month-old rats were treated with either Cerebrolysin or its peptide fraction E021, or saline as a control.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1219766805
06AnimalNot a test of Cerebrolysin aloneAnimal study (in vivo)Efficacy outcome
In aged rats, the Cerebrolysin peptide fraction E021 improved memory compared with saline.
In plain wordsIn rats, the Cerebrolysin peptide fraction E021 improved memory compared with saline.
Peptide
Cerebrolysin
Outcome
IncreaseMemory with E021 fraction
Study
ratn: not reported in source
24-month-old rats
Comparator
Saline
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
These results correlate with the behavioural outcome, revealing an improvement in learning and memory of these rats after treatment with Cerebrolysin and E021.
1 context sentence(design, population, supporting numbers)
Summary · context
In order to examine the effect of the drug on the density of GluR1 in hippocampal formation 24-month-old rats were treated with either Cerebrolysin or its peptide fraction E021, or saline as a control.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-1219766806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.