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Study · Animal study (in vivo) · 2002

1 result

[Effect of structural changes of Pro6 in dermorphin molecule on its antinociceptive activity].

Guzevatykh LS, Emel'ianova TG, Usenko AB, Andreeva LA, Alfeeva LIu, Voronina TA, Miasoedov NF

Izvestiia Akademii nauk. Seriia biologicheskaia1 Jul 2002Cited by 1 (Europe PMC)

PMID12180013 (opens in a new tab)DOI10.1023/a:1016819203043 (opens in a new tab)PepBankPUB-12180013
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In the hot plate test, native dermorphin had a more pronounced antinociceptive effect than the three proline-modified analogs.

    In plain wordsIn animal hot plate tests, native dermorphin reduced pain responses more than the three modified analogs.

    Peptide
    Dermorphin
    Outcome
    IncreaseHot plate antinociceptive activity
    Study

    n: not reported in source

    Hot plate test
    Comparator
    Three dermorphin analogs with modified proline
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    All three dermorphin analogs retained antinociceptive activity in the hot plate test; however, the effect of dermorphin was more pronounced.
    1 context sentence
    Summary · context
    We studied effect of dermorphin (H-Tyr-DAla-Phe-Gly-Tyr-Pro-Ser-NH2) and its analogs with modified amino acid residue proline in position 6, H-Tyr-DAla-Phe-Gly-Tyr-[DPro]-Ser-NH2, H-Tyr-DAla-Phe-Gly-Tyr-[dehydro-Pro]-Ser-NH2, and H-Tyr-DAla-Phe-Gly-Tyr-[D-dehydro-Pro]-Ser-NH2, on nociception in the…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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