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Study · Non-randomized trial · 2002

6 results

Identification, localization and functional activity of oxytocin receptors in epididymis.

Filippi S, Vannelli GB, Granchi S, Luconi M, Crescioli C, Mancina R, Natali A, Brocchi S, Vignozzi L, Bencini E, Noci I, Ledda F, Forti G, Maggi M

Molecular and cellular endocrinology1 Jul 2002Cited by 60 (Europe PMC)

PMID12161007 (opens in a new tab)DOI10.1016/s0303-7207(02)00101-6 (opens in a new tab)PepBankPUB-12161007
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. 1 result from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In oligozoospermic patients in a small single-blind study, an intravenous oxytocin bolus almost doubled sperm retrieval compared with vehicle.

    In plain wordsIn men with low sperm counts in a small study, an oxytocin injection into a vein almost doubled sperm retrieval compared with vehicle.

    Peptide
    Oxytocin
    Outcome
    IncreaseSperm retrieval after oxytocin bolus
    Study

    n: not reported in source

    Comparator
    Vehicle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    2.5 IU · intravenous bolusAs given in this study (human).

    Source sentences

    Summary
    In a small, single blind study, we found that OT almost doubled sperm retrieval when compared with vehicle administration.
    1 context sentence
    Summary · context
    Finally, to investigate whether an acute OT administration increases sperm release also in humans, we treated oligozoospermic patients with an intravenous bolus of OT (2.5 IU), just before sperm collection.
  2. 02LabEx vivo tissueActivity measurement

    In human epididymis, oxytocin signalling stimulated contractility in vitro.

    In plain wordsIn lab tests on human tissue, oxytocin signalling made the epididymis contract more.

    Peptide
    Oxytocin
    Outcome
    IncreaseEpididymal contractility in vitro
    Study

    humann: not reported in source

    human epididymis tissue
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    By using RT-PCR, Western and binding studies, we found that OTR gene and protein is expressed in the human epididymis and stimulates in vitro contractility.
  3. 03LabIn vitro (cells)Mechanism

    In cultured rabbit epididymal epithelial cells, oxytocin induced the release of endothelin-1.

    In plain wordsIn rabbit cells in culture, oxytocin caused the cells to release endothelin-1, another signal that makes the epididymis contract.

    Peptide
    Oxytocin
    Outcome
    IncreaseEndothelin-1 release from epididymal epithelial cells
    Study

    rabbitn: not reported in source

    rabbit epididymal epithelial (rEE) cells in culture
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Experiments performed in rabbit epididymal epithelial (rEE) cells in culture indicate that OT induces the release of an other potent stimulator of epididymal contractility, endothelin-1 (ET-1)

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 04LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    Oxytocin receptor gene and protein were expressed in the human epididymis.

    In plain wordsIn human tissue samples, the receptor that oxytocin binds to was present in the epididymis.

    Peptide
    Oxytocin
    Outcome
    Not applicableOT receptor expression in epididymis
    Study

    humann: not reported in source

    human epididymis tissue
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    By using RT-PCR, Western and binding studies, we found that OTR gene and protein is expressed in the human epididymis
    1 context sentence
    Summary · context
    In this study we investigated on the presence and function of OT receptor (OTR) in rabbit and human epididymis.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 05LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    Immunolocalization showed oxytocin receptor in smooth muscle cells and in the epithelial compartment of the human epididymis.

    In plain wordsIn human tissue samples, the oxytocin receptor was found in smooth muscle cells and in the lining cells of the epididymis.

    Peptide
    Oxytocin
    Outcome
    Not applicableOT receptor localization in epididymis
    Study

    humann: not reported in source

    human epididymis tissue
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    The immunolocalization of OTR suggests that the receptor is not only present in the smooth muscle cells of the human epididymis but also in the epithelial compartment.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 06LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    Blocking the endothelin ET(A) receptor with BQ-123 partially reduced the contractile effect of oxytocin on the epididymis.

    In plain wordsIn lab tests, a drug that blocks the endothelin receptor partly reduced the contraction that oxytocin caused in the epididymis.

    Peptide
    Oxytocin
    Outcome
    DecreaseOT-induced contractility with ET(A) receptor blockade
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Blocking the ET(A) subtype of the ET-1 receptors, by using a specific antagonist (BQ-123), partially counteracts the contractile effect of OT

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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