Skip to content

Study · In vitro (cells) · rat · 2002

4 results

Trophic effects of nootropic peptide preparations cerebrolysin and semax on cultured rat pheochromocytoma.

Safarova ER, Shram SI, Grivennikov IA, Myasoedov NF

Bulletin of experimental biology and medicine1 Apr 2002Cited by 5 (Europe PMC)

PMID12124658 (opens in a new tab)DOI10.1023/a:1016270626439 (opens in a new tab)PepBankPUB-12124658
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured rat PC12 cells, Semax produced no trophic effect, in contrast to cerebrolysin.

    In plain wordsIn cultured rat cells, Semax did not show a trophic effect, while cerebrolysin did.

    Peptide
    Semax
    Outcome
    No significant changeTrophic effect on PC12 cells (differentiation and survival)
    Study

    ratn: not reported in source

    PC12 cell line
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Semax produced no trophic effect on PC12 cells
    1 context sentence
    Summary · context
    Trophic characteristics of neuroprotectors cerebrolysin and semax were evaluated by their capacity to induce differentiation and improve survival of cultured rat pheochromocytoma (PC12) cells.
  2. 02LabIn vitro (cells)Efficacy outcome

    In cultured rat PC12 cells, Cerebrolysin induced morphological differentiation, with enlargement and process formation after 24 h.

    In plain wordsIn cells, Cerebrolysin induced enlargement and process formation after 24 h.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseMorphological cell differentiation
    Study

    ratn: not reported in source

    cultured rat pheochromocytoma (PC12) cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 24 hAs given in this study (rat).

    Source sentences

    Summary
    Morphological signs of cell differentiation (enlargement and formation of processes) were seen 24 h after addition of cerebrolysin into culture medium.
    1 context sentence
    Summary · context
    Trophic characteristics of neuroprotectors cerebrolysin and semax were evaluated by their capacity to induce differentiation and improve survival of cultured rat pheochromocytoma (PC12) cells.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured rat PC12 cells, Cerebrolysin improved survival in serum-free medium.

    In plain wordsIn cells, Cerebrolysin improved survival in medium without serum.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseCell survival in serum-free medium
    Study

    ratn: not reported in source

    cultured rat pheochromocytoma (PC12) cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cerebrolysin improved survival of PC12 cells in serum-free medium.
    1 context sentence
    Summary · context
    Trophic characteristics of neuroprotectors cerebrolysin and semax were evaluated by their capacity to induce differentiation and improve survival of cultured rat pheochromocytoma (PC12) cells.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cultured rat PC12 cells, Cerebrolysin at 100 microg/ml reduced apoptotic cells from 32% in control to 10%.

    In plain wordsIn cells, Cerebrolysin reduced apoptotic cells to 10%, compared with 32% in control.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseApoptotic cell proportion
    Study

    ratn: not reported in source

    cultured rat pheochromocytoma (PC12) cells
    Comparator
    Control
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    100 microg/mlAs given in this study (rat).

    Measurements

    Apoptotic cells
    32%
    control
    Apoptotic cells
    10%
    cerebrolysin

    Source sentences

    Summary
    In a concentration of 100 microg/ml cerebrolysin decreased the content of apoptotic cells from 32% (control) to 10%.
    1 context sentence
    Summary · context
    Trophic characteristics of neuroprotectors cerebrolysin and semax were evaluated by their capacity to induce differentiation and improve survival of cultured rat pheochromocytoma (PC12) cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 14Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 11 times, first on 14 Oct 2026, 05:02 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    14 Oct 2026, 01:46 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    9 Oct 2026, 19:08 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.