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Study · In vitro (cells) · 2002

4 results

Oxytocin modulates estrogen receptor alpha expression and function in MCF7 human breast cancer cells.

Cassoni P, Catalano MG, Sapino A, Marrocco T, Fazzari A, Bussolati G, Fortunati N

International journal of oncology1 Aug 2002Cited by 28 (Europe PMC)

PMID12118334 (opens in a new tab)DOI10.3892/ijo.21.2.375 (opens in a new tab)PepBankPUB-12118334
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In MCF7 human breast cancer cells, oxytocin treatment down-regulated estrogen receptor alpha mRNA levels from the first 24 h.

    In plain wordsIn cells from a human breast cancer line, oxytocin lowered the messenger RNA level of the estrogen receptor alpha.

    Peptide
    Oxytocin
    Outcome
    DecreaseERalpha mRNA level
    Study

    humann: not reported in source

    MCF7 human breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Since the first 24 h of OT treatment the ERalpha mRNA levels are down-regulated
    1 context sentence
    Summary · context
    Besides this effect, we report that OT modulates the expression of estrogen receptor alpha (ERalpha) in MCF7 cells, both at mRNA and protein level.
  2. 02LabIn vitro (cells)Mechanism

    In MCF7 human breast cancer cells, oxytocin treatment decreased estrogen receptor alpha protein expression at a later time than mRNA.

    In plain wordsIn cells from a human breast cancer line, oxytocin lowered estrogen receptor alpha protein, later than it lowered the messenger RNA.

    Peptide
    Oxytocin
    Outcome
    DecreaseERalpha protein expression
    Study

    humann: not reported in source

    MCF7 human breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    in contrast, ERalpha protein expression decreases at a later time
    1 context sentence
    Summary · context
    Besides this effect, we report that OT modulates the expression of estrogen receptor alpha (ERalpha) in MCF7 cells, both at mRNA and protein level.
  3. 03LabIn vitro (cells)Mechanism

    In MCF7 human breast cancer cells, oxytocin treatment temporarily increased the binding affinity of estrogen receptor alpha.

    In plain wordsIn cells from a human breast cancer line, oxytocin briefly raised how strongly the estrogen receptor alpha binds its target.

    Peptide
    Oxytocin
    Outcome
    IncreaseERalpha binding affinity
    Study

    humann: not reported in source

    MCF7 human breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    a temporary increase in the binding affinity of these receptors
    1 context sentence
    Summary · context
    Besides this effect, we report that OT modulates the expression of estrogen receptor alpha (ERalpha) in MCF7 cells, both at mRNA and protein level.
  4. 04LabIn vitro (cells)Mechanism

    In MCF7 human breast cancer cells, oxytocin treatment significantly increased the estradiol-induced transcription activity of estrogen receptor alpha.

    In plain wordsIn cells from a human breast cancer line, oxytocin raised the estrogen receptor alpha response to estradiol.

    Peptide
    Oxytocin
    Outcome
    IncreaseE2-induced ERalpha transcription activity
    Study

    humann: not reported in source

    MCF7 human breast cancer cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    a significant increase in their estradiol (E2)-induced transcription activity
    1 context sentence
    Summary · context
    Besides this effect, we report that OT modulates the expression of estrogen receptor alpha (ERalpha) in MCF7 cells, both at mRNA and protein level.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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