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Study · Measured the body's own peptide · 2002

5 results

Cholecystokinin stimulation leads to increased oxytocin secretion in women.

Ohlsson B, Forsling ML, Rehfeld JF, Sjölund K

The European journal of surgery = Acta chirurgica1 Jan 2002Cited by 42 (Europe PMC)

PMID12113268 (opens in a new tab)DOI10.1080/11024150252884340 (opens in a new tab)PepBankPUB-12113268
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelNon-randomized trialMechanism

    There was no difference between healthy and constipated women in oxytocin secretion.

    In plain wordsHealthy women and women with constipation showed no difference in release of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin secretion, healthy versus constipated women
    Study

    n = 14

    Comparator
    Healthy women
    Analysis
    Primary
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    There was no difference between healthy and constipated women in either parameter analysed.
    2 context sentences
    Summary · context
    8 healthy female volunteers and 6 women with chronic refractory normal-transit constipation.
    Summary · context
    On one day they were given emulsified corn oil and another an intravenous injection of 1 Ivy dog unit (IDU) CCK/kg body weight.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelNon-randomized trialMechanism

    In healthy women, corn oil ingestion increased oxytocin secretion (p = 0.02).

    In plain wordsIn healthy women, eating corn oil raised the body's own oxytocin release.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin secretion after corn oil, healthy women
    Study

    n = 8

    Analysis
    Primary
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The corn oil increased oxytocin secretion in both groups (p = 0.02 and 0.03, respectively) and exogenous CCK increased the secretion still further (p = 0.008 and 0.03, respectively).
    2 context sentences
    Summary · context
    8 healthy female volunteers and 6 women with chronic refractory normal-transit constipation.
    Summary · context
    On one day they were given emulsified corn oil and another an intravenous injection of 1 Ivy dog unit (IDU) CCK/kg body weight.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelNon-randomized trialMechanism

    In healthy women, intravenous CCK increased oxytocin secretion still further than corn oil (p = 0.008).

    In plain wordsIn healthy women, a CCK injection raised the body's own oxytocin release even more than corn oil.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin secretion after exogenous CCK, healthy women
    Study

    n = 8

    Analysis
    Primary
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The corn oil increased oxytocin secretion in both groups (p = 0.02 and 0.03, respectively) and exogenous CCK increased the secretion still further (p = 0.008 and 0.03, respectively).
    2 context sentences
    Summary · context
    8 healthy female volunteers and 6 women with chronic refractory normal-transit constipation.
    Summary · context
    On one day they were given emulsified corn oil and another an intravenous injection of 1 Ivy dog unit (IDU) CCK/kg body weight.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelNon-randomized trialMechanism

    In women with normal-transit constipation, corn oil ingestion increased oxytocin secretion (p = 0.03).

    In plain wordsIn women with constipation, eating corn oil raised the body's own oxytocin release.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin secretion after corn oil, women with constipation
    Study

    n = 6

    Analysis
    Primary
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The corn oil increased oxytocin secretion in both groups (p = 0.02 and 0.03, respectively) and exogenous CCK increased the secretion still further (p = 0.008 and 0.03, respectively).
    2 context sentences
    Summary · context
    8 healthy female volunteers and 6 women with chronic refractory normal-transit constipation.
    Summary · context
    On one day they were given emulsified corn oil and another an intravenous injection of 1 Ivy dog unit (IDU) CCK/kg body weight.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelNon-randomized trialMechanism

    In women with normal-transit constipation, intravenous CCK increased oxytocin secretion still further than corn oil (p = 0.03).

    In plain wordsIn women with constipation, a CCK injection raised the body's own oxytocin release even more than corn oil.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin secretion after exogenous CCK, women with constipation
    Study

    n = 6

    Analysis
    Primary
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    The corn oil increased oxytocin secretion in both groups (p = 0.02 and 0.03, respectively) and exogenous CCK increased the secretion still further (p = 0.008 and 0.03, respectively).
    2 context sentences
    Summary · context
    8 healthy female volunteers and 6 women with chronic refractory normal-transit constipation.
    Summary · context
    On one day they were given emulsified corn oil and another an intravenous injection of 1 Ivy dog unit (IDU) CCK/kg body weight.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 stopped early · source ClinicalTrials.gov (opens in a new tab)

WithdrawnPhase not statedNCT01008371

Investigation of Neuro-hormonal Mechanisms of Hunger, Fullness and Obesity.

Medical University of South Carolinan = 0Oct 2009 to Mar 2013

Obesity · Gastric Emptying · Anxiety · Depression · Panic Disorder

Trial pageClinicalTrials.govUpdated 22 May 2013

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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