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Study · Animal study (in vivo) · rat · 2002

3 results

[Effect of the novel dipeptide nootropic agent noopept and its metabolite cyclo-L-prolylglycine on the transcallosal evoked potential in the rat brain].

Molodavkin GM, Borlikova GG, Voronina TA, Gudasheva TA, Ostrovskaia RU, Tushmalova NA, Seredenin SB

Eksperimental'naia i klinicheskaia farmakologiia1 Mar 2002

PMID12109288 (opens in a new tab)PepBankPUB-12109288
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, noopept increased transcallosal evoked potential amplitude, which plateaued and remained elevated throughout observation beyond 3.5 hours.

    In plain wordsIn rats, noopept increased the brain response amplitude, which remained at a plateau beyond 3.5 hours.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseTranscallosal evoked potential amplitude
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both noopept and cyclo-L-prolylglycine also increased the TEP amplitude, which attained a plateau and retained this level over the entire observation time (above 3.5 h).
    1 context sentence
    Summary · context
    The effect of new nootropic dipeptides--noopept (N-phenylacetyl-L-prolylglycine, GVS-111) and its metabolite (cyclo-L-prolylglycine)--and a standard nootrope piracetam on the transcallosal evoked potential (TEP) in rat brain was studied.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, noopept increased the positive component of the transcallosal evoked potential.

    In plain wordsIn rats, noopept increased the positive component of the brain response.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreasePositive evoked potential component
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All the nootropes studied increased both components of the evoked potential.
    2 context sentences
    Summary · context
    Piracetam and cyclo-L-prolylglycine led to an approximately equal increase in both waves, while noopept induced a somewhat greater increase in the negative TEP wave amplitude.
    Summary · context
    The effect of new nootropic dipeptides--noopept (N-phenylacetyl-L-prolylglycine, GVS-111) and its metabolite (cyclo-L-prolylglycine)--and a standard nootrope piracetam on the transcallosal evoked potential (TEP) in rat brain was studied.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, noopept increased the negative transcallosal wave amplitude somewhat more than the positive wave amplitude.

    In plain wordsIn rats, noopept increased the negative brain response wave somewhat more than the positive wave.

    Peptide
    Noopept (omberacetam)
    Outcome
    IncreaseNegative evoked potential component
    Study

    ratn: not reported in source

    Comparator
    positive TEP wave amplitude
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Piracetam and cyclo-L-prolylglycine led to an approximately equal increase in both waves, while noopept induced a somewhat greater increase in the negative TEP wave amplitude.
    2 context sentences
    Summary · context
    All the nootropes studied increased both components of the evoked potential.
    Summary · context
    The effect of new nootropic dipeptides--noopept (N-phenylacetyl-L-prolylglycine, GVS-111) and its metabolite (cyclo-L-prolylglycine)--and a standard nootrope piracetam on the transcallosal evoked potential (TEP) in rat brain was studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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