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Study · Measured the body's own peptide · 2002

2 results

Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques.

Rosenblum LA, Smith EL, Altemus M, Scharf BA, Owens MJ, Nemeroff CB, Gorman JM, Coplan JD

Psychoneuroendocrinology1 Aug 2002Cited by 39 (Europe PMC)

PMID12084658 (opens in a new tab)DOI10.1016/s0306-4530(01)00056-7 (opens in a new tab)PepBankPUB-12084658
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    Pigtail macaques had significantly lower CSF oxytocin concentrations than bonnet macaques.

    In plain wordsIn macaques, the more volatile pigtail species had lower levels of the body's own oxytocin in spinal fluid than the bonnet species.

    Peptide
    Oxytocin
    Outcome
    DecreaseCSF oxytocin concentration, pigtail versus bonnet macaques
    Study

    macaquen: not reported in source

    Bonnet and pigtail macaques, CSF radioimmunoassay
    Comparator
    Bonnet macaques
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    significant lower concentrations of CSF OT than bonnet macaques.
    1 context sentence
    Summary · context
    Cisternal CSF samples were obtained from young adult male and female pigtail and bonnet macaques, and CRF and OT concentrations were measured by radioimmunoassay.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In multiple regression, CSF CRF and oxytocin together gave a multiple R of 0.76 and accounted for more than half of the species variance.

    In plain wordsIn macaques, spinal fluid levels of CRF and the body's own oxytocin together explained more than half of the difference between species.

    Peptide
    Oxytocin
    Outcome
    Not applicableVariance in species difference explained by CRF and oxytocin (multiple regression)
    Study

    macaquen: not reported in source

    Bonnet and pigtail macaques, CSF radioimmunoassay
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Measurements

    Multiple R
    0.76 R
    CRF and OT, species variance

    Source sentences

    Summary
    When included together in a multiple regression, CRF and OT showed a multiple R of 0.76, accounting for more than half of the species variance.
    1 context sentence
    Summary · context
    Cisternal CSF samples were obtained from young adult male and female pigtail and bonnet macaques, and CRF and OT concentrations were measured by radioimmunoassay.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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